TyChucks Cancer Drugs buzzwords

Question 1

prevents HER2 recepter dimerization

Answer 1

“pertu”zumab (almost like “perty girl” aka a dime)

Question 2

prevents HER2 receptor binding

Answer 2

trustuzumab

Question 3

TK inhibitor effective against chronic myeloid leukemia

Answer 3

Imatinib

Question 4

TK inhibitor effective against non-small cell lung cancer… and the 10% mutation in ____ receptor that responds well to it

Answer 4

Gefitinib

EFGR mutation pts respond well to it

Question 5

antibody against VEGF

Answer 5

bevacizumab

Question 6

name 2 TK inhibitors of VEGF

Answer 6

sunitinib & sorafinib

Question 7

HDAC inhibitor

Answer 7

Suberoylanilide hydroxamic acid (keep chromatin open)

Question 8

methylation inhibitors

Answer 8

azacytidine & decitabine

Question 9

urinalysis of this metabolite indicates increased cancer metastasis

Answer 9

sarcosine

Question 10

drugs that alleviate chemo drug sypmtoms

Answer 10

(serotonin antagonist)

Dolasetran/palonosetran

Question 11

alkylating agent that treats chronic leukemia (along with imatinib)

Answer 11

chlorambucil

Question 12

alk. agent that requires metabolism and toxic effect = hair loss

Answer 12

cyclophosphamide

Question 13

CNS tumors!

Answer 13

carmustin (BCNU)

Question 14

primary myelosuppression

Answer 14

busulfan

Question 15

effective against many solid tumors (inhibits DNA synth and alters dna template activity)

Answer 15

Gemcitabine

Question 16

analogous to trimethprim & gets polyglutamated

Answer 16

Methotrexate – cuz it inhibits dihydrofolate reductase

Question 17

can rescue from methotrexate toxicity

Answer 17

folinic acid

Question 18

What is the commonality between pyrimidine and purine analogues?

Answer 18

REQUIRE METABOLISM to monophosphate level to be incorporated into cell cycle

Question 19

inhibitor of thymidilate synthetase

Answer 19

5-FU-monophosphate

Question 20

treats acute leukemia but causes weakness tremors and convulsions

Answer 20

vincristine

Question 21

effective against solid tumors (like gemcitibine) but also against hodgkins disease and testicular tumors

Answer 21

vinblastine

Question 22

Name 3 cancer drugs that work analogously to fluoroquinolone antibiotics and important notes on each

Answer 22

1) etoposide —> testicular cancer
2) tocotepan —> ovarian and lung cancer
3) doxorubicin —> causes cardiac toxicity (along with trestuzumab)
* All 3 inhibit topisomerase activity… thus are cycle active

Question 23

effective against solid tumors but VERY toxic and works by inhibiting RNA polymerase

Answer 23

Actinomycin D

Question 24

acts very similarly to vinblastine (treats solid tumors, testicular cancer, and lymphomas) but has a unique toxicity to cause pulmonary fibrosis

Answer 24

Bleomycin

Question 25

effectiveness of this drug will be decreased if patient is also taking paxil/prozac antidepressants

Answer 25

Tamoxifen

Question 26

the active metabolite of tamoxifen

Answer 26

endoxifen

Question 27

List 4 cancer drug groups that require metabolism (aka given as a pro-drug) before having an effect

Answer 27

1) cyclophosphamide
2) purine analogues (6-mercapto & thioguanisine)
3) pyrimidine analogues (5-FU)
4) tamoxifen

Question 28

This cancer chemo drug should not be given to pts with renal impairment

Answer 28

Methotrexate

Question 29

Name 3 anti-estrogen drugs

Answer 29

1) tamoxifen
2) exemestane*
3) anastrozole*
* aromatase inhibitors

Question 30

this must also be given with anti-androgen drug flutamide

Answer 30

leuprolide (LHRH analogue to prevent further synthesis of ganodotropins from pituitary… castration also works)

Question 31

cisplatin toxicity is decreased with these 2 things (hint… it causes nephrotoxicity)

Answer 31

1) hydration

2) manitol diuresis

Question 32

cancers cisplatin is used to treat

Answer 32

solid tumors… in the head/neck, ovaries, bladder, testicles

Question 33

drug inhibits synthesis of purines and pyrimidines

Answer 33

hydroxyurea

Question 34

who is the most high yield classmate @ CHM

Answer 34

ali quixote