Tx of Hyperlipidemia

Question 1

What is the mechanism of statins?

Answer 1

inhibit HMG-CoA reductase

Question 2

What is the effect of statins on lipids?

Answer 2

decrease LDL, triglycerides, HDL

Question 3

What is the mechanism of Niacin?

Answer 3

decrease adipose lipase activity

Question 4

What is the effect of Niacin on lipids?

Answer 4

decrease LDL, triglycerides and HDL

Question 5

What is the mechanism of Fibric Acid?

Answer 5

activate hepatic PPAR-alpha

Question 6

What is the effect of Fibric Acid on lipids?

Answer 6

decrease Triglycerides LDL and HDL

Question 7

What is the mechanism of Bile Resins?

Answer 7

prevent bile acid absorption

Question 8

What is the effect of Bile Resins on lipids?

Answer 8

decreases LDL

Question 9

What is the mechanism of Ezetimibe?

Answer 9

Inhibits intestinal cholesterol absorption

Question 10

What is the effect of Ezetimibe on lipids?

Answer 10

decreases LDL

Question 11

examples of fibrates (2)

Answer 11

1. Fenofibrate (Tricor)

2. Gemfibrozil (Lopid)

Question 12

examples of bile acid-binding resins

Answer 12

1. cholestyramine (Questran)
2. Colesevelam (Welchol)
3. Colestipol (Colestid)

Question 13

example of a sterol uptake inhibitor

Answer 13

Ezetimibe (Zetia)

Question 14

combo medication:

Simcor (made up of?)

Answer 14

1. extended release niacin + simvastatin

Question 15

combo medication:

Vytorin (made up of?)

Answer 15

Ezetimibe + simvastatin