Two Component Systems Flashcards
What are the two components?
A sensor kinase (usually membrane bound) and a response regulator (usually DNA binding protein; cytoplasmic)
What does a two component system do?
They mostly regulate gene expression in response to change in the environment
How does it work?
On detecting a specific stimulus, the sensor kinase auto-phosphorylates (on a histidine) and transfers the phosphate to an aspartate on the response regulator which is then active
What is unusual about the ArcB-ArcA two-component system?
It is an unorthodox system, meaning ArcB has two additional phosphorylatable domains so there are two routes for phosphorylation of response regulator, ArcA
What is unusual about the NarX/NarQ - NarL/NarP two-component system?
Is is a dual two-component system. Two sensor kinases, NarX and NarQ, and two response regulators NarL and NarP
What is unusual about CheA-CheY two-component system?
It regulates flagellar movement rather than gene expression
