tutoring review cards set Flashcards
which of the following occurs first in somatic recombination of T cell alpha chain genes?
a. D-J joining
b. V-D joining
c. J-C joining
d. V-J joining
d. V-J joining
In which of the following cells are RAG1 and RAG2 not expressed? a. Pro-B cell b. Pre-B cell c. B cell D. plasma cell
D. Plasma cell
Surrogate light chains are characteristic of which cell type?
a. Pro-B cell
b. Pre-B cell
c. B cell
d. Plasma cell
b. Pre-B cell
Which of the following statements best represents allelic exclusion?
a. If a heavy chain of a BCR comes from a maternal allele the light chain must also be maternal
b. if a heavy chain of a BCR comes from a maternal allele, the light chain must be paternal
c. the H chain alleles expressed on a single B cell must all be maternal or all be paternal
D. the H chain alleles on a single B cell can come from maternal and paternal alleles
c. the H chain alleles expressed on a single B cell must all be maternal or all be paternal
The variable domain of the heavy chain protein is comprised of which of the following?
a. the V region of the gene sequence
b. the VD region o the gene sequence
c. the VDJ region of the gene sequence
d. the VDJC region of the gene sequence
c. the VDJ region of the gene sequence
You have a petri dish full of CD4+ T cells. You throw in some IL-1, IL-6, IL-23. What cells do you find when you examine the Petri dish again?
a. Th1 cells
b. Th2 cells
c. Th17 cells
d. Treg cells
c. Th17 cells
You have a petri dish full of CD4+ T cells. You throw in some IL-4. What cells do you find when you examine the Petri dish again?
a. Th1 cells
b. Th2 cells
c. Th17 cells
d. Treg cells
b. Th2
You look into a pertri dish at some unknown cells that produce IFN-gamma. What of the following types of cells are they?
a. Th1 cells
b. Th2 cells
c. Th17 cells
d. Treg cells
a. Th1 cells
Which T cell subset mediate alternative activation of macrophages?
a. Th1 cells
b. Th2 cells
c. Th17
d. Treg cells
B. Th2 cells
You walk into a dark immunology lab, with a single light shining on a Petri dish. You are drawn to it; you must look at it. As you examine it, you realize that these cells express high levels of FoxP3. What are you looking at?
a. Th1 cells
b. Th2 cells
c. Th17 cells
d. Treg cells
d. Treg cells
Which pairings of cells have anti-inflammatory functions?
a. Th1 and Tregs
b. Th2 and Th17
c. Th2 classically activated macrophages
d. Tregs and alternatively activated macrophages
d. Tregs and alternatively activated macrophages
A young girl is ill with an unknown pathogen. It is discovered that the pathogen is identified by a polysaccharide antigen. The medical team conjugates the antigen in a vaccine and administers it to her brother, who has never encountered this pathogen. Which is false about the immune responses of the two children?
a. The girl’s antibodies will be secreted into the intestinal lumen
b. the girl’s antibodies will not undergo hypermutation
c. the boy will have antibodies that can more efficiently bind antigen
d. the boy will create more antibodies that inhibit their own production
a. The girl’s antibodies will be secreted into the intestinal lumen
A person deficient in AID will not be able to undergo which of the following processes?
a. Fc receptor signaling
b. Thymus antigen presentation
c. Isotype switching
d. VDJ recombination
c. isotype switching
Which of the following about germinal centers is true?
a. Follicular dendritic cells presents progressively more antigen to B cells until the infection is completely cleared
b. every mutation involved in affinity maturation ensures that an antibody with higher affinity will result
c. T follicular helper cells contain the Fas ligand that kills B cells
d. B cells hypermutation in the dark zone of the GC
d. B cells hypermutation in the dark zone of the GC
Which of the following is not characteristic of memory B cells?
a. they express the protein Bcl-2
b. they may circulate between lymphoid organs
c. they are responsible for a quicker and more robust reaction to subsequent antigen exposures
d. they are typically induced by exposure to TI antigens
d. they are typically induced by exposure to TI antigens
they are TD
