Tutorial 2 Questions Flashcards
True or false
The H gene codes for the O antigen
False
The H gene codes for the H antigen, there is no such things as an O antigen
If both potential parents are group O, what blood type could their offspring be?
O
A friend tells you that he knows he is blood type A and his wife is type B. Their newborn child is type O. Assuming no technical error, how is this possible?
Both parents are heterozygous for the ABO alleles
A couple is going through fertility therapy in their attempt to have a child. One potential parent is type AB. The other is type O. What are the ABO blood type possibilities for their child?
A or B
What are the chances of a type AB parent and a type O parent having 3 consecutive type A children
12.5%
Chance of type A child is 1 in 2 or 50%
3 consecutive children is 0.5 x 0.5 x 0.5 = 0.125 or 12.5%
True or false
ABO is the only blood group system in which reciprocal antibodies are normally produced for the antigens an individual lacks AND the ABO antibodies are capable of causing rapid, intravascular haemolysis
True
Parents with which two ABO groups can potentially produce offspring with ALL of the common four blood types?
A and B
Heterozygous carrying O
True or false about Anti-A and Anti-B antibodies
Usually IgM but can be a mixture of IgM, IgG and IGA
True
True or false about Anti-A and Anti-B antibodies
React optimally at RT but can bind complement at 37 degrees Celsius
True
True or false about Anti-A and Anti-B antibodies
Transfusion and pregnancy can stimulate production of IgG and anti-A and anti-B which can cross the placenta and cause HDFN
True
Individuals with the Bombay phenotype can only be transfused with RBC from donors of the Bombay phenotype because
- All non-Bombay phenotype donors will have the H antigen on their RBC
- Individuals with the Bombay phenotype have non-red cell stimulated (NRCS or naturally occurring) anti-H
- Donors with the Bombay phenotype have no A, B or H antigens on their RBC
