Tutorial 1 Questions

Question 1

A primary immune response involves

Answer 1

The production of IgM antibodies following the first exposure to a foreign antigen

Question 2

True or false:

IgG antibodies are pentamers

Answer 2

False. They are monomers

Question 3

True or false:

IgM antibodies do not fix complement

Answer 3

False

Question 4

The factors affecting antigen-antibody reactions include

Answer 4

• Temperature
• pH and ionic strength
• Antigen density and antibody concentration

Question 5

The classic complement pathway is activated by

Answer 5

Ag-Ab complexes

Question 6

Complement amplifies both innate and adaptive immune responses by

Answer 6

• Promoting acute inflammation and recruiting macrophages
• Marking target cell surfaced to encourage phagocytosis
• Disrupting the integrity of target cell membranes leading to eventual cell lysis

Question 7

True or false:
Routine transfusion testing or pre-transfusion testing involves determining the presence or absence of the expected anti-A and anti-B antibodies in the donor plasma

Answer 7

False. Generally testing on donor plasma isn’t performed, but RBC testing is