Tut Q's

Question 1

Which of the following glucocorticoids is MOST potent?

Answer 1

Dexamethasone

Question 2

Which of the following is a metabolic precursor for cortisol?

Answer 2

Cholesterol

Question 3

Which of the following is a metabolic precursor for prostaglandins PGs?

Answer 3

Arachidonic acid

Question 4

Which of the following is NOT a typical adverse drug reaction/side effect of glucocorticoid therapy?

Answer 4

Hemorrhagic cystitis

Question 5

Which of the following receptors is NOT trans-membrane receptor?

Answer 5

Glucocorticoid receptor

Question 6

Which of the following side effects/adverse drug reactions are more likely to be seen in animals treated with chronic/long term prednisolone therapy?

Answer 6

Alopecia, muscle atrophy on abdominal wall, central obesity.

Question 7

In which of the following conditions glucocorticoids should not be used and/or are contraindicated?

Answer 7

Eye corneal ulcers.

Question 8

Of the alternatives below, which one best describes glucocorticoid medicines in order of increasing duration of action DOA?

Answer 8

Hydrocortisone, prednisolone, dexamethasone.

Question 9

Alternative anti-pruritic therapies to glucocorticoids include the following, except:

Answer 9

Rimexolone

Question 10

Which of the following best describes the mechanism of action MOA of cyclosporine?

Answer 10

Calcineurin inhibitor.

Question 11

Which the following medicines is a janus kinase 1inhibitor?

Answer 11

Oclacitnib

Question 12

A monoclonal antibody with anti-pruritic action is:

Answer 12

Lokivetmab

Question 13

Regarding the mechanism of action of lokivetmab, which of the following is the drug target it acts against?

Answer 13

Interleukin-31

Question 14

Which of the following medicines is a cytotoxic drug which inhibits purine synthesis?

Answer 14

Azathioprine

Question 15

Of the alternatives below, which one best describes immunosuppressive drugs which are cytotoxic?

Answer 15

Azathioprine, cyclophosphamide, chlorambucil.

Question 16

Which of the following medicines does NOT affect prostaglandins and leukotrienes production?

Answer 16

Cyclosporine

Question 17

Which of the following medicines is most likely to cause haemorrhagic cystitis?

Answer 17

Cyclophosphamide.

Question 18

Which of the following medicines is a cytotoxic drug which is highly toxic to cats?

Answer 18

Azathiprine

Question 19

Which of the following medicines is most likely to cause gingival hyperplasia?

Answer 19

Cyclosporine

Question 20

Which of the following is the most appropriate dose of prednisolone for treatment of immune mediated haemolytic anaemia in dogs?

Answer 20

2mg/kg/day

Question 21

Regarding muscle atrophy due to chronic/long term glucocorticoid therapy, which body areas are most likely to be affected?

Answer 21

Abdominal wall, dorsal spine, pelvis.

Question 22

Glucocorticoids bind to which of the following types of receptors?

Answer 22

Intracytoplasmic receptors.

Question 23

Which of the following glucocorticoids is LEAST potent?

Answer 23

Hydrocortisone

Question 24

Which of the following medicines decreases the formation of inflammatory mediators prostaglandins and leukotrienes by inhibition of phospholipase A2?

Answer 24

Dexamethasone & Prednisolone

Question 25

Which of the following drugs works by binding to the glucocorticoid receptor?

Answer 25

Loteprednol

Question 26

Which of the following best describes cytotoxic medicines that are alkylating agents?

Answer 26

Chlorambucil, cyclophosphamide.