Tumour Lysis Syndrome Flashcards
1
Q
What is TLS usually triggered by? [1]
A
Induction of combination chemotherapy
but can also be triggered by sterod treatment alone
2
Q
What are the typical electrolyte changes seen in TLS? [3]
What else is raised? [1]
A
High K
High P
Low Ca
Raised Uric acid
3
Q
What treatment should you give for TLS? [3]
A
IV fluids
Allopurinol or rasburicase (metabolises uric acid to allantoin)
BUT: shouldnt give allopurinol and rasburicase together as reduces effects of rasburicase
4
Q
Which drugs can you give to prevent TLS? [2]
A
Allopurinol or rasburicase
5
Q
What clinical findings do you need alongisde lab results for a TLS diagnosis? [3]
A
Increased serum creatitine (1.5x upper limit of normal)
Cardiac arrthmia or sudden death
Seizure
