Tumour Development 2 Flashcards
What is a locus
A specific position where a sequence of nucleotide is based
What is an allele?
Genes located on the same location of 2 homologous chromosomes
Name the 5 methods of dna damage
Deletion
Duplication
Inversion
Insertion
Translocation
What is deletion
Point mutation, when a section of gene is deleted
What is duplication
When a section of DNA is duplicated
What is inversion
When a section breaks off but attaches again in the reverse orientation
What is insertion
When a base pair gets added in a DNA segment
What is translocation
2 diff chromosomes
When one piece of a chromosome breaks off and attaches to another chromosome
Examples of oncogenes growth factors
PDGF - brain cancer
What does herceptin mAB drug
Binds intercellular
stops cell proliferation and stops development
Enhances chemo effects
Examples of oncogenes cytoplasmic relays
K ras - activated by growth factor receptors for lungs
N ras - leukaemia
Examples of tumour suppressor genes
pRB protein - brake on cell cycle for lungs
p53 - halts cell cycle in G1 and causes cell suicide
What do we need tumour classification
Accurate diagnosis and treatment
Accurate exchange of into
To define clinical subgroups
To facilitate epidemiology analysis
Name the 3 histogenic sub groups of malignant tumours
Carcinoma
Sarcoma
Lymphoma
