Tumour Definitions HN1-23 VNs Flashcards
Layers of Epidermis & Cells in each layer
Corneum - dead keratinocytes Lucidum Granulosum Spinosum - keratinocytes, langerhan cells Basale - Merkel cell, Melanocytes
Acanthosis
thicker spinosum layer of skin
Anaplasia
change of cell to less highly differentiated form
atrophy
decrease in size of cell, organ or tissue after full development
Define Carcinoma in situ
o Growth disturbance in which there is sufficient atypicality of the epithelial cells and their arrangement to warrant the diagnosis of cancer in the absence of invasion
Choristoma
mass of histologically normal tissue in abnormal location
Teratoma
tumour with 1-3 germinal layers and has different tissue that don’t occur together or at the site of the tumour
**strict definition: all 3 germinal layers
Desmoplasia
connective tissue reaction to tumour
Dyskeratosis
keratin produced at lower layers of skin
Dysplasia
change in size, shape or orientational relationship
Ectopic
normal tissue, abnormal location
Hemartoma
circumscribed overgrowth of tissue that is NORMALLY found in that part of the body
Hyperkeratosis
increased thickness of keratinized layers
Hyperplasia
increase in number of cells/unit of tissue
Hypertrophy
increase in individual cell size
Keratoacanthosis
increase in spinosum layer and keratosis
Metaplasia
differentiation of cell into another type
Metastasis
secondary discontinuous cancer growths
Neoplasm
proliferation of cells to form a mass
Parakeratosis
retention of nuclei in cells that get to the stratum corneum (normally dead keratinocytes)
Pleomorphism
more than one form of a single cell type
Cell Repair
cell proliferation to repair and restore towards normal structure and function
