Tumour antigens Flashcards
Give examples of tumour-specific antigens?
virus-encoded proteins; idiotypes of B and T cell tumours; mutated cellular proteins
Give examples of tumour-associated antigens?
over-expresed cellular proteins; tissue-specific differentiation antigens; expression of silent genes
What type of latency is seen in Burkitt’s lymphoma?
type 1
What EBV protein is expressed in Burkitts lymphoma with type 1 latency?
EBNA1
What type of latency is expressed in Hodgkins lymphoma?
type 2
What EBV proteins are expressed in Hodgkins lymphoma?
EBNA1; LMP1, 2
What type of latency is seen in lymphoproliferative disease in the immunocompromised?
type 3
What is the possibility of understanding the EBV proteins expressed in different cancers?
CTLs have been used to taret EBV + Hodgkins disease targeting LMP1 and LMP2-Bollard et al
What is meant by the B and T cell idiotype?
the binding site of hte Ig or TcR is clone-specific: tumours originate from a single lymphocyte
How can the B cell idiotypes be used to create vaccinations?
find the tumour specific Ig and present to DCs which can then be transferred back into patient resulting in idiotype-specific CTLs nad CD4 cells—tumour regression–Hsu et al
Give an example of a mutated cellular protein in CML?
bcr/abl
What is the philidelphia chromosme in CML?
fusion of chromsomes 9 and 22 results in expression of a fusion oncoprotein bcr-abl with tyrosine kinase activity
give examples of tumour specific antigen vaccinations?
DC vaccintion in B cell lymphoma (idiotypes) - Hsu; vaccination against bcr-abl fusion protein in CML - Bocchia
Give examples of over-expressed proteins in cancers?
p53; mdm2; telomerase
What has been the pooled response data in ALL with CD19-specific CARs?
80% clinical response
