Tumors Flashcards
What is the most common pigmented lesion in lighter skinned individuals?
Ephils/freckles
What is the most deadly skin cancer?
melanoma
What is the most common malignant skin tumor?
basal cell carcinoma
What are ephils?
(appearance and histologic features)
Ephils = freckles
hyperpigmented macule, darkens with sun exposure
increased melanosomes** (normal melanocytes)
Where and in what populations are ephils most commonly seen?
lighter skin
What is lentigo?
(appearance and histologic features)
benign melanocyte hyperplasia
darkened macule/papules (do not change w/ sun exposure)
linear (lentiginous) spread of melanocytes above the basal layer
Where and in what populations is lentigo most commonly seen?
No preference for race, gender, or age
frequently begins in childhood and progresses throughout lifetime
What are nevi?
(appearance)
nevus = mole
benign melanocyte neoplasm
uniformly darkend macule/papule, well defined borders , typically <6mm (opposite of ABCDE of melanoma)
What are the histologic features/types of nevi?
Junctional nevi:
- nest of cells along dermoepidermal junction in the epidermis
- macule (flat) > papule
- most common in children
Compound nevi:
- growth of nests through junction into dermis
- papule (raised) > macule
Intradermal nevi:
- loss of epidermal component, only dermal now; nests -> cords
- papule (raised) > macule
- most common in adults
General progression:
junctional -> compound -> intradermal
Blue nevi:
- black/blue; non-nested; dendritic; fibrosis
- commonly mistaken as melanoma
What are dysplastic nevi?
(appearance and histologic features)
(significance of frequency)
potential precursor of melanoma
- darkend macules; “pebbly” surface; darker, raised center with lighter irregular periphery
- more in line with ABCDE of melanoma
- coalesced nests
- fibrosis of Rete ridges
How do nevi relate to melanoma?
What non-skin cancer are they also associated with?
Dysplastic nevi are less likely to develop into melanoma themselves (although they can) than they are indicative of an increased risk for development of melanoma
Dysplastic nevus syndrome
-autosomal dominant disorder
- 2 or more atypical nevi -or- >100 typical nevi
- associated with 50% incidence of melanoma by age 60
- increased risk of pancreatic cancer
What is melanoma?
(appearance)
malignant melanocyte neoplasm
ABCDE:
- Asymmetry
- irregular Border
- non-uniform Color
- Diameter >6mm
- Evolution
flat or nodular depending on subtype
What are the histologic features/types of melanoma?
(associated prognosis)
Lentigo maligna:
- lentigious growth (radial growth limited to basal layer)
- most common on face of older men
- good prognosis, indolent
Superficial spreading:
-dominant early radial growth
-good prognosis
Acral lentiginous growth:
- lentiginous growth (unrelated to sun exposure)
- can affect mucous membranes, nail beds, palms, and soles
- most common in dark skinned individuals
Nodular:
- dominant early vertical growth
- poor prognosis
Where are the different subtypes of melanoma most commonly seen?
Superficial spreading/nodular:
- sun exposed areas
- backs of men
-extremities of women
Lentigo maligna:
- sun exposed areas
- face of older men
Acral lentiginous:
- independent of sun exposure
- dark skinned populations
- palms, soles, nailbeds, mucous membranes
What are the risk factors for developing melanoma?
- UVB exposure (particulalry severe exposures in childhood rather than cumulative exposure)
- fair skin
- light colored eyes (green/blue)
- dysplastic nevus syndrome (>100 typical or at least 2 atypical)
What is the most important prognostic factor of melanoma?
Breslow thickness:
- depth from granular layer to deepest portion of tumor
- thicker = worse
What is seborrheic keratosis?
(appearance and histologic features)
benign squamous proliferation
- discolored, coin-like, waxy plaques
- uniform color
- spontaneously arise
- keratin pseudocysts
Where and in what populations is seborrheic keratosis most commonly seen?
elderly
-trunk, extremities, head, neck
What is Leser-Trélat sign?
sudden eruption of multiple seborrheic ketaroses indicating possible GI carcinoma
What is acanthosis nigricans?
(appearance and histologic features)
Epidermal hyperplasia
- thick, hyperpigmented
- acanthosis (epidermal hyperplasia)
- papilmatosis (hyperplasia of dermal papilae)
Where and in what populations is acanthosis nigricans most commonly seen?
- interignious/flexor surfaces (axila, groin, neck)
- benign versions typically present in childhood and progress into adulthood; diabetics and obese
- paraneoplastic typically in middle aged men