Tumor Type By Histology

Question 1

Poorly defined infiltrative tumor

Increased glial cellularity with nuclear pleomorphism and fibrillary appearance

Answer 1

Diffuse infiltrative astrocytoma

Question 2

Densely cellular glial tumor with high pleomorphism and mitotic figures

Answer 2

Anaplastic astrocytoma

Question 3

Highly cellular glioma with high pleomorphism and mitotic figures coupled with pseudopallisading necrosis and/or vascularity/tuft like glomeruloid bodies.

Answer 3

Glioblastoma (multiforme)

Question 4

Solid or cystic with nodule and microscopic long, hair-like processes and Rosenthal fibers

Answer 4

Pilocytic astrocytoma

Question 5

Circumscribed mass with bizarre and pleomorphic cells without necrosis , sometimes lipidized astrocytic in the temporal lobe. Reticulin deposits present

Answer 5

Pleomorphic Xanthoastrocytoma

Question 6

Well circumscribed with multiple cysts, calcification and focal hemorrhage. Spherical nuclei with lots of granular chromatin with clear halo of cytoplasm. If infiltrative, exhibits perineuronal satellite cells

Answer 6

Oligodendroglioma

Question 7

Well demarcated with regular and round/oval chromatin filled nuclei forming canals or glandular structures. Often have perivascular pseudorosettes that extend thin processes toward the vessel wall. Hint: Often arise in 4th ventricle

Answer 7

Ependymoma

Question 8

Cuboidal cells with clear cytoplasm forming papillae in background of neutral to acidic polysaccharides

Answer 8

Myxopapillary ependymoma

Tends toward spinal cord

Question 9

Irregularly clustered ganglion cells, including binucleate forms. Surrounding glia have increased pleomorphism and cellularity but not necrosis or mitotic figures

Answer 9

Ganglioglioma

Question 10

Discrete intracortical nodules of small round cells that cluster around neurons in a much polysaccharide background

Answer 10

DNET

Question 11

Evenly spaced round nuclei with neuronal markers

Answer 11

Central neurocytoma

Question 12

Midline tumor that is extremely cellular with sheets of anaplastic cells that include scant cytoplasm, hyper chromatic nuclei that are elongated or crescent shaped. Abundant mitosis and high proliferation and can express neuronal or glial stating. Homer right rosettes are also a hallmark.

Answer 12

Medulloblastoma

Question 13

Rhabdoid cells including Eosinophilic cytoplasm with sharp so borders and eccentrically located nuclei. Can also have you located cytoplasm that looks like a rhabdomyosarcoma. Can also have islands of tumor of next small cell morphology. Lots of mitosis.

Answer 13

Atypical teratogenic/rhabdoid tumor (ATRT)