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CNS Tumor Markers > Tumor Markers-Tumor Type > Flashcards

Tumor Markers-Tumor Type Flashcards

1
Q

GFAP

A

Astrocytoma

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2
Q

Loss of heterozygosity 1p and q19

A

Oligodendroglioma (WHO II) good prognosis as long as no other changes that raise grade to III/IV (deletion 9p, 10q or CDKN2A)

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3
Q

NF2 mutation

A

Ependymoma

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4
Q

Ki-67 (high proliferation) and GFAP
Loss of 17p-poor prognosis
MYC amplification -poor prognosis

Rare SHH, WNT -better prognosis
Trkc-better prognosis

A

Medulloblastoma

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5
Q

Epithelial membrane antigen + (EMA +)
Vimentin +

Chromosome 22 deletion of hSNF5/IN11 (protein lost in staining)

A

ATRT

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CNS Tumor Markers (4 decks)

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