Tumor Suppressors Flashcards by Sarah Lopez | Brainscape

Q

APC

A

Colorectal cancer (associated w/Familial adenomatous polyposis)

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

BRCA 1/2

A

DNA repair

Breast and ovarian cancers

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

DCC

A

Colon Cancer

Deleted in Colon Cancer

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

DPC4/SMAD4

A

Pancreatic cancer

Deleted in Pancreatic Cancer

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

MEN1

A

Menin

MEN1

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

NF1

A

Ras GTPase activating protein

Neurofibromatosis 1

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

NF2

A

Merlin (schwannomin) protein

Neurofibromatosis 2

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

p16

A

CDK inhibitor

Melanoma

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

p53

A

TF that blocks G1 to S phase transition

Li-Fraumeni, most human cancers

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

PTEN

A

Breast, prostate, endometrial cancers

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Rb

A

Inhibits E2F; blocks G1 to S phase transition

Retinoblastoma, osteosarcoma

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

TSC1

A

Hamartin protein

Tuberous sclerosis

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

TSC2

A

Tuberin protein

Tuberous sclerosis

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

VHL

A

Inhibits hypoxia inducible factor 1a

von Hippel-Lindau disease, renal cell carcinoma

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

WT1/2

A

Wilms tumor

How well did you know this?

1

Not at all

2

3

4

5

Perfectly