Tumor suppressor gens

Question 1

in order to have a loss of fxn both alleles have to be lost

T/F

Answer 1

true

opposite of oncogenes

Question 2

Gene APC

Answer 2

colorectal cancer(assoc with FAP)

Question 3

BRACA1/BRACA2

Answer 3

breast an ovarian cancaers

loss of DNA repair protein

Question 4

Gene CDKN2A

Answer 4

melanoma/pancreatic caner

defective p16 which orginally blocks G1-S phase

Question 5

Gene DCC

Answer 5

colon cancer

DCC= Deleted in colon cancer

Question 6

Gene DPC4/SMADA

Answer 6

pancreatic cancer

DPC=deleted in pancrease cancer

Question 7

Gene MEN1

Answer 7

MEN1 (mult. endocrine neoplasia)

menin

Question 8

Gene NF1

Answer 8

neurofibromatosis type 1

Ras GTPase activating protein (neurofibromin)

Question 9

NF2

Answer 9

neurofibromatosis type 2

Merlin (schwannomin) protein

Question 10

Gene PTEN

Answer 10

breast cancer, prostate cancer, endometrial cancer

Question 11

Gene Rb

Answer 11

RetinoBlastoma, osteoscaroma

inhibits E2F, blocks G1-S phase

Question 12

Gene Tp53

Answer 12

Most human cancers, Li-Fraumeni syndrome

p53 activates p21 which blocks G1-S phase

Question 13

Gene TSC1

Answer 13

Tuberous Sclerosis

Hamartin protein defective

Question 14

Gene TSC1

Answer 14

Tuberous Scleroris

tuberin protein defective

Question 15

Gene VHL

normal fxn of gene

Answer 15

Von-Hippel-Lindau disease, renal cell carincoma

inhibitis hypoxia inducible factor 1a

Question 16

Gene WT1/WT2

Answer 16

Wilms tumor (nephroblastoma)