Oncogenes Flashcards by David Evans | Brainscape

Q

T/F you only beed to damage 1 allele to increase risk for cancer?

A

True

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Q

Gene ALK

-receptor tyrosine kinase

A

lung adenocarcinoma

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Q

Gene BCR-ABL

-tyrosine kinase

A

CML (chronic myeloid leukemia)

ALL (acute lymphoblastic leukemia)

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Q

Gene BCL-2

antiapoptotic

A

follicular and diffuse large B cell lymphomas

note: BCL sound like B cell

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Q

Gene BRAF

serine/threonine kinase

A

melanoma, non-hodgkin lymphoma

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Q

gene c-KIT

cytokine receptor

A

gastrointestinal stromal tumor (GIST)

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Q

Gene c-MYC

transcription factor

A

Burkitt lymphoma

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Q

Gene HER2/neu(c-erbB2)

tyrosine kinase

A

breast and gastric carinomas

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Q

Gene JAK2

tyrosine kinase

A

chronic myelophroliferative disorders

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Q

Gene KRAS

GTPase

A

colon cancer, lung cancer, pancreatic cancer

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Q

Gene MYCL1

trasncription factor

A

lung tumor

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Q

Gene MYCN

transcription factor

A

neuroblastoma

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Q

Gene RET

tyrosine kinase

A

MEN 2A and 2B, medullary thyroid cancer

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