Tumor suppressor genes and associated tumor Flashcards

1
Q

APC

A

colorectal cancer (associated w/ FAP)

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2
Q

BRCA1

A

Breast and ovarian cancer

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3
Q

BRCA2

A

Breast and ovarian cancer

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4
Q

CPD4/SMAD4

A

Pancreatic cancer

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5
Q

DCC

A

Colon cancer

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6
Q

MEN1

A

MEN type I

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7
Q

NF1

A

Neurofibromatosis type 1

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8
Q

NF2

A

Neurofibromatosis type 2

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9
Q

p16

A

Melanoma

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10
Q

p53

A

Most human cancers, Li-Fraumeni syndrome

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11
Q

PTEN

A

breast cancer, prostate cancer, endometrial cancer

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12
Q

Rb

A

Retinoblastoma, osteosarcoma

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13
Q

TSC1

A

Tuberous sclerosis

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14
Q

TSC2

A

Tuberous sclerosis

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15
Q

VHL

A

von Hippel-Lindau dz

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16
Q

WT1

A

Wilms Tumor (nephoblastoma)

17
Q

WT2

A

Wilms Tumor (nephroblastoma)