Tumor suppressor genes and associated tumor Flashcards
1
Q
APC
A
colorectal cancer (associated w/ FAP)
2
Q
BRCA1
A
Breast and ovarian cancer
3
Q
BRCA2
A
Breast and ovarian cancer
4
Q
CPD4/SMAD4
A
Pancreatic cancer
5
Q
DCC
A
Colon cancer
6
Q
MEN1
A
MEN type I
7
Q
NF1
A
Neurofibromatosis type 1
8
Q
NF2
A
Neurofibromatosis type 2
9
Q
p16
A
Melanoma
10
Q
p53
A
Most human cancers, Li-Fraumeni syndrome
11
Q
PTEN
A
breast cancer, prostate cancer, endometrial cancer
12
Q
Rb
A
Retinoblastoma, osteosarcoma
13
Q
TSC1
A
Tuberous sclerosis
14
Q
TSC2
A
Tuberous sclerosis
15
Q
VHL
A
von Hippel-Lindau dz