Tumor suppressor genes Flashcards by Julius Riazonda | Brainscape

Q

2 important tumor suppressor genes

Governor of the cell cycle
Guardian of the genome
Exerts antiproliferative effects by controlling G1-S checkpoint in the cell cycle
Regulates cell cycle progression, DNA repair, cellular senescence, and apoptosis

A

Rb
p53
Rb
p53

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Most frequently mutated tumor-suppressor gene in human cancers

A

p53

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Rb

A

Retinoblastoma
Osteosarcoma

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

p53

A

Most human cancers
Li-Fraumeni syndrome

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

APC

A

Colorectal cancer (associated with FAP)

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

PTEN

A

Breast cancer
Prostate cancer
Endometrial cancer

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

NF1, NF2

A

Neurofibromatosis type 1, Neurofibromatosis type 2

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

WT1

A

Wilms tumor (nephroblastoma)

How well did you know this?

1

Not at all

2

3

4

5

Perfectly