Oncogenes Flashcards
1
Q
Most common type of abnormality
A
RAS
2
Q
ALK
A
Lung adenocarcinoma
- Memory aid:*
- Lung AdenoKarcinoma
3
Q
BCR-ABL
A
CML, ALL
4
Q
BCL-2
A
Follicular and diffuse large B cell lymphomas
5
Q
BRAF
A
- Hairy cell leukemia
- Melanoma
- Non-Hodgkin lymphoma
- Papillary thyroid carcinoma
6
Q
c-KIT
A
Gastrointestinal stromal tumor (GIST)
7
Q
MYC
- c-MYC
- MYCL1
- MYCN
A
- c-MYC
- Burkitt lyphoma
- MYCL1
- Lung tumor
- MYCN
- Neuroblastoma
8
Q
HER2/neu (c-erbB2)
A
Breast and gastric carcinomas
9
Q
JAK2
A
Chronic myeloproliferative disorders
10
Q
KRAS
A
- Colon cancer
- Lung cancer
- Pancreatic cancer
11
Q
RET
A
- MEN 2A and 2B
- Medullary thyroid cancer
12
Q
EGFR
A
Lung
13
Q
RAS
A
Many cancer
14
Q
CDK4
A
Glioblastoma
