tumor suppressor genes Flashcards by Zahra Ismail | Brainscape

Q

APC

A

Colorectal cancer

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Q

BRCA

A

DNA repair protein

breast and ovarian cancer

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Q

DCC

A

deleted in colon cancer

colon cancer

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Q

DPC/SMAD

A

deleted in pancreatic cancer

pancreatic cancer

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Q

MEN1

A

menin

MEN 1

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Q

NF1

A

Ras GTPase activating protein (neurofibromin)

neurofibromatosis 1

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Q

NF2

A

Merlin (schwannomin) protein

neurofibromatosis 2

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Q

p16

A

cyclin-dependent kinase inhibitor 2A

melanoma

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Q

p53

A

TF for p21, blocks G1–>S phase

most human cancers, Li-Fraumeni syndrome

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Q

PTEN

A

breast, prostate, endometrial cancer

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Q

Rb

A

inhibits E2F; blocks G1–>S phase

retinoblastoma, osteosarcoma

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Q

TSC1

A

hamartin protein

tuberous sclerosis

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Q

TSC2

A

tuberin protein

tuberous sclerosis

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Q

VHL

A

inhibits hypoxia inducible factor 1a

von Hippel-Lindau disease, renal cell carcinoma

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Q

WT1/WT2

A

Wilms tumor- nephroblastoma

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