oncogenes Flashcards
1
Q
BCR-ABL
A
Tyrosine kinase
CML, ALL
2
Q
BCL-2
A
Anti-apoptotic molecule
follicular lymphoma
3
Q
BRAF
A
Serine/threonine kinase
Melanoma, non-hodgkin lymphoma
4
Q
c-kit
A
cytokine receptor
gastrointestinal stromal tumor (GIST)
5
Q
c-myc
A
TF
burkitt lymphoma
6
Q
n-myc
A
TF
neuroblastoma
7
Q
l-myc
A
TF
lung tumor
8
Q
HER2/neu (c-erbB2)
A
tryrosine kinase
breast, ovarian, gastric carcinoma
9
Q
RAS
A
GTPase
colon, lung, pancreatic cancer
10
Q
RET
A
tryrosine kinase
MEN 2A, MEN2B, medullary thyroid cancer