Tumor Suppressor Genes Flashcards by Brandon Tomlin | Brainscape

Q

APC

A

Colorectal cancer, 1st step

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Q

BRCA1

A

Breast and ovarian cancer

DNA repair protein

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Q

BRCA2

A

Breast and ovarian cancer

DNA repair protein

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Q

CPD4/SMAD4

A

Pancreatic cancer

DPC

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Q

DCC

A

Colon cancer

DCC

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Q

MEN1

A

MEN1

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Q

NF1

A

Neurofibromatosis 1

RAS GTPase activating protein

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Q

P16

A

Melenoma

Cyclin dependent kinase inhibitor 2A

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Q

P53

A

Li-Fraumeni

Blocks G1 to S phase

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Q

PTEN

A

Breast, Prostate, endometrial cancer

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Q

Rb

A

Retinoblastoma, osteosarcoma

inhibits E2F; blocks G1 to S phase

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Q

TSC1

A

Tuberous sclerossis

Hamartin protein

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Q

VHL

A

von Hippel Lindau

inhibits hypoxia inducible factor 1a

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Q

WT1

A

Whilms Tumor

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Q

NF2

A

Neurofibromatosis 2

Merlin (schwannomin) protein

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Q

TSC2

A

Tuberous sclerosis

Tuberin protein