oncogenes Flashcards

1
Q

BCR-ABL

A

CML, ALL

Tyrosine Kinase

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2
Q

bcl-2

A

Follicular and undifferentiated lymphoma

Anti-apoptosis gene

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3
Q

BRAF

A

Melanoma

Serine/threonine kinase

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4
Q

c-kit

A

Gastrointestinal stromal tumor

Cytokine receptor for stem cell factor

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5
Q

c-myc

A

Burkett lymphoma

transcription factor

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6
Q

HER2/neu

A

Breast, ovarian, and gastric carcinoma

tyrosine kinase

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7
Q

L-myc

A

Lung Tumor

transcription factor

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8
Q

N-Myc

A

Neuroblastoma

transcription factor

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9
Q

ras

A

Colon cancer, lung cancer, pancreatic cancer

GTPase

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10
Q

ret

A

Men 2A and 2B

Tyrosine kinase

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