Tumor Suppresor Genes Review

Question 1

What is the action of APC gene?

Answer 1

Negatively regulates B-catenin by signaling for its breakdown

Question 2

What cancers are associated with mutations of the APC gene?

Answer 2

Familial adenomatous polyposis, colorectal carcinoma and melanoma

Question 3

What is the function of the BRCA1 and BRCA2 gene?

Answer 3

Encodes proteins involved in DNA repair

Question 4

If there is a mutation in the BRCA1 and BRCA2 gene what cancers can occur?

Answer 4

Breast carcinoma and ovarian carcinoma

Question 5

What is the function of the NF1 tumor suppressor gene?

Answer 5

Encodes tumor suppressor protein neurofibromin

Question 6

What happens if there is a mutation in the NF1 gene?

Answer 6

Neurofibromatosis type 1 which can lead to the development of neuroblastomas and sarcomas

Question 7

What is the function of the MEN1 gene?

Answer 7

Encodes tumor suppressor protein menin

Question 8

What happens if there is a mutation in the MEN1 gene?

Answer 8

MEN1, parathyroid, pituitary, and pancreatic adenomas

Question 9

Hahah is the function of the RB gene?

Answer 9

Encodes for the retinoblastoma protein

Question 10

What happens if there is a mutation in the RB gene?

Answer 10

Retinoblastoma and osteosarcoma

Question 11

What is the function of the VHL gene?

Answer 11

Inhibits hypoxia inducible factor 1a (HIF1a)

Question 12

What happens if there is a mutation in the VHL gene?

Answer 12

VHL disease
Renal cell cancer

Question 13

What is the function of the WT1 gene?

Answer 13

Encodes for Wilms tumor protein which regulates gene activity

Question 14

What happens if there is a mutation of the WT1 gene?

Answer 14

Wilms tumor

Question 15

What is the function of the TP53 gene?

Answer 15

Encodes for tumor protein 53

Question 16

What cancers are associated with mutations of the TP53 gene?

Answer 16

Most human carcinomas
Li-Fraumeni syndrome