Proto Oncongenes Review Flashcards
PDGFB action?
Encodes platelet endothelial growth factor
Plays a physiological role in blood vessel growth
What is the mechanism of PDGFB?
Autocrine loop overexpression
PDGFB is associated with which type of cancer?
Astrocytoma
What is the action of ERBB1/EGFR?
Tyrosine kinase
-encodes epidermal growth factor receptor
The ERBB1/EGFR is associated with what types of cancer?
Glioblastoma, adenocarcinoma of the lung, head and neck carcinomas
ERBB2/HER2/neu action?
Tyrosine kinase
The ERBB2/HER2/neu gene is associated with what types of cancer?
Breast carcinoma and ovarian carcinoma
What is the action of the RET gene?
Encodes for neural growth factor receptor
If there is a point mutation in the RET gene what cancers can arise?
Múltiple endocrine neoplasia (MEN) 2A, 2B, medullary thyroid cancer, pheochromocytoma
What is the action of the BCL-2 gene?
Anti apoptotic molecule
What happens if there is a translocation between chromosomes 14 and 18 involving the BCL-2 gene?
Follicular B cell lymphoma
What is the action of the KIT gene?
Encodes stem cell growth factor receptor
What cancers can arise if there is a point mutation in the KIT gene?
Gastrointestinal stromal tumor
What is the function of the RAS gene?
Encodes for a GTP binding protein
What cancers can arise if there is a point mutation in the RAS gene?
Carcinoma of the lung, colon, pancreas
Melanoma and lymphoma
What is the function of the ABL gene?
Encodes for a tyrosine kinase
What happens if there is a chromosome 2 translocation and inversion leading to a fusion gene called EML4-ALK?
It can lead to large cell lymphoma and non small cell lung cancer
What is the function of the c-MYC gene?
Encodes for a tyrosine kinase
What happens if there is a translocation between chromosomes 8 and 14 ?
It can lead to burkitts lymphoma
What is the function of the gene N-MYC?
Encodes for a transcription factor
What happens if the N-MYC gene is amplified?
It can lead to a neuroblastoma
What is the function of the L-MYC gene?
Encodes for a transcription factor
What happens if there is a amplification of the L-MYC gene?
It can lead to small cell lung cancer
What is the function of the CCND1 ( cyclin D1)
Produces cyclin
What happens if there is a translocation between chromosomes 11 and 14?
It can lead to mantle cell lymphoma
What is the function of CDK4 gene?
Cyclin dependent kinase
What happens if the CDK4 gene is amplified?
It can lead to the development of melanoma
