tumor of vascular origin Flashcards
vascular tumors
intralymphatic histiocytosis is related to what rheumatoid disease?
rheumatic arthritis
histopathology: dilated blood vessels containing in their lumen capillaries surrounded by pericytes
glomeruloid hemangioma
2 syndromes connected with glomeruloid hemangioma
POEMS polyneuropathy oegnanomegaly endocrinopathy M-protein and skin lesions (crow0fukase) syndrome)
cattleman
Electrom microscopy with large lysosomes containing fat vacuoles and cellular debris
thanatosomes
most common form of vascular malformation
salmon patvch
pink na port winner stain
nevus roseus
alin sa nevus flames ang hindi nagiinvolute
port wine stain - rarely involutes
salmon patch - spontaneously involutes
gene mutation in portwine
RASA1 same with AV mslformation
syndromes related to portwine and their body location
eyes- sturge-weber
back - Cobb
limbs - klippel-trenaunay
secondary tumors that can occur in port wine
PG - pewee din after laser
tufted angioma
bcc
histopathology of nevus flames
ecstatic blood vessels in the dermis with different caliberas
histopathology: dilated capillaries and venues in the superficial dermis with true vascular proliferation
cutis marmorata telangiectatica congenita
adam-oliver connected with aplasia cutis congenita
3 conditions where spider nevus are seen
liver disease
thyrotoxicosis
preggy
histopathology: dilated arteriole connected with dilated superficial capillaries
spider nevus
gene mutation and what chromosome number is affected in portwine stain
GNAQ chromosome 9
vascular tumor in sun damage lip of elderly
with hitopath of dilated and congested vein
venous lake
vascular tumor that represents
1) ectasia of superficial capillaries that are congersted with 2 epidermal changes:
a) . acanthosis
b) hyperkeratosis
angiokeratoma
difference ng angiokeratoma and verrucous hemangioma
verrucous hemangioma nasa superficial and deep and dilated blood vessels and angiokeratoma ay superficial
syndrome related to angiokeratoma
anderson-fabry syndrome
warty blue nodule on the extremities with dilated capillaries n the whole dermis with acanthosis and hyperkeratosis
verrous venous malformation (don’t use verrucous hemangioma)
other term for arteriovenous malformation
cirsoid aneurysm
reddish blue papule less than 1 cm diameter
with histopathology of dilated thick walled BV on dermis up to subQ with plump endothelium, thick muscular walls and micro thrombi and caclification
arteriovenous malformation )cirsoid aneurysm
lobules of dilated or congested capillaries surrounded by layers of pericytes. each lobules are surrounded by fibrosis with inflammation, bigger BV calcification and hemosiderin
RAPIFLY INVOLUTING CONGENITAL HEMANGIOMA
STAIN OF GLUT-1 IN RICH
GLUT-1 NEGATIVE pero sometimesd postive sa tumor lobules
CAUSE OF Regression in RICH
infarction
histopathology of NICH
tumor lobules din of capillaries but sometimes Malaki young vessels sa look ng lobules
gLUT-1 negative din sya
with arteriovenous fistula din aka mo cissoid aneuryssm
difference between development of RiCH NICH and infantile hemangioma
RICH - develops BEFORE birth
NICH- AT birth
infantile hemangioma- develops AFTER birth
other term for infantile hamangioma (2)
strawberry nevus; juvenile hemangioma
most important ddx of infantile hemangioma
RICH and NICH kazoo and strawberry nevus walling fibrosis
most common vascular tumors of childhood
infantile hemangioma
the only vascular tumor positive for. GLUT-1 and WT-1
infantile hemnagioma
what is infantile hemangioma? tumor or hamrtoma?
hamartoma
quasi may endothelial cells, pericytes and fibroblasts
flat red <5cm raised papule with intradermal or subq of multi lobular proliferation of small vascular spaces with plump endothelial cells with MITOSIS! with perineurial invasion
infantile hemangioma - clonal
postive stains for infantile hemangioma
negative for PROX-1
reticulin stain- vascular channels in early bags magdilate sa late
2) GLUT-1 ; WT-1
3) LYVE-1 and CD34- sa endothelial cells that are plump. negative na sya paginvoluting stage na meaning that the endothelial cells are arrested early
histpath of abortive hemangioma
- patch - vascular channels sa superficial and then lobules of capillaries sa deep
papule shows capillary hemangioma features
other term for cherry angioma
senile angioma
campbell de morgan spots
vascular tumor that is a polypoid lesion with epidermal collarette; lobules of dilated and congested vessels in the papillary dermis
cherry angioma
co-existence of of lobular capillary hemangioma
port wine stain or if port wine stain is treated with pulse dye
NF-1 von hippel-lindau syndrome
3 types of pyogenic granuloma and there location
1) granuloma gravidarum - gingival of prey involutes after delivery
2) subcutaneous and deep dermal - upper limb
30 intravenous lobular - neck and upper ext
exophytic lobulated dermal mass with numerous capillaries radiating with central bigger vessels in a loose edematous collagenous matrix
mitosis are common
endothelial cells are plump or bland esp in mucosa mukhang epithelia
lobular capillary hemangioma
with superficial acute and chronic inflammation especially with ulcerated lesions and the adjacent epidermis is acanthoticc
kelan lang nya walang ulceration and inflammation ang PG?
kqpag deeper dermis ang pyogenic granuloma
etiology of pyogenic granuloma
BRAF V600E and RAS
RAS/ERK
most important differential of pyogenic granuloma
bacillary angiomatosis
-caused by ROchalimaea henselae
pero ito pale eosinophilic endothelium and positive for giemsa and warthog starry
difference ng PG with angiosarc if Pareto silang may plump endothelial cells and mitotic figures
pg- lobular architecture
other term for tufted angioma
angiolastoma of nakagawa
presence in th dermis and subq round or oval lobes of tights knit capillaries with cresent shaped dilated lymphatic space adjacent to the lobule, surrounded din Ito ng pericytes just like strawberry nevus
with crystalline inclusion bodies
tufted angioma
type of lymphocyte increased in tufted angioma
CD8+ - meaning cytotoxic mediated immune system
tufted angioma stains
1) endothelial cells
2) lymphatic
3) vessel
1) endothelial cells- CD31 and ERG
2) lymphatic - D2-40
3) WT-1 or GLUT -1
difference of strawberry nevus from tufted angioma
strawberry nevus - more extensive hanging baba and also absence of adjacent present shape lymphatic
difference ng tufted angioma sa kaposi sarcoma
may cannonball and tufted and spindle shape naan and kaposi
bluish red tumor that is a vascular malformation with proliferation of dilated blood vessels in superficial dermis with flattened endothelial cells and it is not lobular. no epidermal collarette
cavernous hemangioma
variant of cavernous hemangioma with markedly dilated lobular back-to back congested vascular channels in sieve like pattern
sinusoidal hemangioma
difference between sinusoidal hemangioma with angiosarc
as infiltrative and atypical; with mitotic figures and angiosarc
