tumor of vascular origin Flashcards by chesca quinio

intralymphatic histiocytosis is related to what rheumatoid disease?

rheumatic arthritis

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histopathology: dilated blood vessels containing in their lumen capillaries surrounded by pericytes

glomeruloid hemangioma

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2 syndromes connected with glomeruloid hemangioma

POEMS polyneuropathy oegnanomegaly endocrinopathy M-protein and skin lesions (crow0fukase) syndrome)

cattleman

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Electrom microscopy with large lysosomes containing fat vacuoles and cellular debris

thanatosomes

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most common form of vascular malformation

salmon patvch

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pink na port winner stain

nevus roseus

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alin sa nevus flames ang hindi nagiinvolute

port wine stain - rarely involutes

salmon patch - spontaneously involutes

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gene mutation in portwine

RASA1 same with AV mslformation

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syndromes related to portwine and their body location

eyes- sturge-weber
back - Cobb
limbs - klippel-trenaunay

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secondary tumors that can occur in port wine

PG - pewee din after laser
tufted angioma
bcc

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histopathology of nevus flames

ecstatic blood vessels in the dermis with different caliberas

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histopathology: dilated capillaries and venues in the superficial dermis with true vascular proliferation

cutis marmorata telangiectatica congenita

adam-oliver connected with aplasia cutis congenita

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3 conditions where spider nevus are seen

liver disease
thyrotoxicosis
preggy

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histopathology: dilated arteriole connected with dilated superficial capillaries

spider nevus

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gene mutation and what chromosome number is affected in portwine stain

GNAQ chromosome 9

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vascular tumor in sun damage lip of elderly

with hitopath of dilated and congested vein

venous lake

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vascular tumor that represents

1) ectasia of superficial capillaries that are congersted with 2 epidermal changes:
a) . acanthosis
b) hyperkeratosis

angiokeratoma

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difference ng angiokeratoma and verrucous hemangioma

verrucous hemangioma nasa superficial and deep and dilated blood vessels and angiokeratoma ay superficial

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syndrome related to angiokeratoma

anderson-fabry syndrome

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warty blue nodule on the extremities with dilated capillaries n the whole dermis with acanthosis and hyperkeratosis

verrous venous malformation (don’t use verrucous hemangioma)

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other term for arteriovenous malformation

cirsoid aneurysm

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reddish blue papule less than 1 cm diameter

with histopathology of dilated thick walled BV on dermis up to subQ with plump endothelium, thick muscular walls and micro thrombi and caclification

arteriovenous malformation )cirsoid aneurysm

lobules of dilated or congested capillaries surrounded by layers of pericytes. each lobules are surrounded by fibrosis with inflammation, bigger BV calcification and hemosiderin

RAPIFLY INVOLUTING CONGENITAL HEMANGIOMA

STAIN OF GLUT-1 IN RICH

GLUT-1 NEGATIVE pero sometimesd postive sa tumor lobules

CAUSE OF Regression in RICH

infarction

histopathology of NICH

tumor lobules din of capillaries but sometimes Malaki young vessels sa look ng lobules gLUT-1 negative din sya with arteriovenous fistula din aka mo cissoid aneuryssm

difference between development of RiCH NICH and infantile hemangioma

RICH - develops BEFORE birth NICH- AT birth infantile hemangioma- develops AFTER birth

other term for infantile hamangioma (2)

strawberry nevus; juvenile hemangioma

most important ddx of infantile hemangioma

RICH and NICH kazoo and strawberry nevus walling fibrosis

most common vascular tumors of childhood

infantile hemangioma

the only vascular tumor positive for. GLUT-1 and WT-1

infantile hemnagioma

what is infantile hemangioma? tumor or hamrtoma?

hamartoma | quasi may endothelial cells, pericytes and fibroblasts

flat red <5cm raised papule with intradermal or subq of multi lobular proliferation of small vascular spaces with plump endothelial cells with MITOSIS! with perineurial invasion

infantile hemangioma - clonal

postive stains for infantile hemangioma negative for PROX-1

reticulin stain- vascular channels in early bags magdilate sa late 2) GLUT-1 ; WT-1 3) LYVE-1 and CD34- sa endothelial cells that are plump. negative na sya paginvoluting stage na meaning that the endothelial cells are arrested early

histpath of abortive hemangioma

- patch - vascular channels sa superficial and then lobules of capillaries sa deep papule shows capillary hemangioma features

other term for cherry angioma

senile angioma campbell de morgan spots

vascular tumor that is a polypoid lesion with epidermal collarette; lobules of dilated and congested vessels in the papillary dermis

cherry angioma

co-existence of of lobular capillary hemangioma

port wine stain or if port wine stain is treated with pulse dye NF-1 von hippel-lindau syndrome

3 types of pyogenic granuloma and there location

1) granuloma gravidarum - gingival of prey involutes after delivery 2) subcutaneous and deep dermal - upper limb 30 intravenous lobular - neck and upper ext

exophytic lobulated dermal mass with numerous capillaries radiating with central bigger vessels in a loose edematous collagenous matrix mitosis are common endothelial cells are plump or bland esp in mucosa mukhang epithelia

lobular capillary hemangioma

with superficial acute and chronic inflammation especially with ulcerated lesions and the adjacent epidermis is acanthoticc kelan lang nya walang ulceration and inflammation ang PG?

kqpag deeper dermis ang pyogenic granuloma

etiology of pyogenic granuloma

BRAF V600E and RAS | RAS/ERK

most important differential of pyogenic granuloma

bacillary angiomatosis -caused by ROchalimaea henselae pero ito pale eosinophilic endothelium and positive for giemsa and warthog starry

difference ng PG with angiosarc if Pareto silang may plump endothelial cells and mitotic figures

pg- lobular architecture

other term for tufted angioma

angiolastoma of nakagawa

presence in th dermis and subq round or oval lobes of tights knit capillaries with cresent shaped dilated lymphatic space adjacent to the lobule, surrounded din Ito ng pericytes just like strawberry nevus with crystalline inclusion bodies

tufted angioma

type of lymphocyte increased in tufted angioma

CD8+ - meaning cytotoxic mediated immune system

tufted angioma stains 1) endothelial cells 2) lymphatic 3) vessel

1) endothelial cells- CD31 and ERG 2) lymphatic - D2-40 3) WT-1 or GLUT -1

difference of strawberry nevus from tufted angioma

strawberry nevus - more extensive hanging baba and also absence of adjacent present shape lymphatic

difference ng tufted angioma sa kaposi sarcoma

may cannonball and tufted and spindle shape naan and kaposi

bluish red tumor that is a vascular malformation with proliferation of dilated blood vessels in superficial dermis with flattened endothelial cells and it is not lobular. no epidermal collarette

cavernous hemangioma

variant of cavernous hemangioma with markedly dilated lobular back-to back congested vascular channels in sieve like pattern

sinusoidal hemangioma

difference between sinusoidal hemangioma with angiosarc

as infiltrative and atypical; with mitotic figures and angiosarc