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mckee dermpath > tumor of vascular origin > Flashcards

tumor of vascular origin Flashcards

vascular tumors

1
Q

intralymphatic histiocytosis is related to what rheumatoid disease?

A

rheumatic arthritis

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2
Q

histopathology: dilated blood vessels containing in their lumen capillaries surrounded by pericytes

A

glomeruloid hemangioma

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3
Q

2 syndromes connected with glomeruloid hemangioma

A

POEMS polyneuropathy oegnanomegaly endocrinopathy M-protein and skin lesions (crow0fukase) syndrome)

cattleman

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4
Q

Electrom microscopy with large lysosomes containing fat vacuoles and cellular debris

A

thanatosomes

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5
Q

most common form of vascular malformation

A

salmon patvch

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6
Q

pink na port winner stain

A

nevus roseus

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7
Q

alin sa nevus flames ang hindi nagiinvolute

A

port wine stain - rarely involutes

salmon patch - spontaneously involutes

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8
Q

gene mutation in portwine

A

RASA1 same with AV mslformation

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9
Q

syndromes related to portwine and their body location

A

eyes- sturge-weber
back - Cobb
limbs - klippel-trenaunay

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10
Q

secondary tumors that can occur in port wine

A

PG - pewee din after laser
tufted angioma
bcc

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11
Q

histopathology of nevus flames

A

ecstatic blood vessels in the dermis with different caliberas

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12
Q

histopathology: dilated capillaries and venues in the superficial dermis with true vascular proliferation

A

cutis marmorata telangiectatica congenita

adam-oliver connected with aplasia cutis congenita

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13
Q

3 conditions where spider nevus are seen

A

liver disease
thyrotoxicosis
preggy

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14
Q

histopathology: dilated arteriole connected with dilated superficial capillaries

A

spider nevus

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15
Q

gene mutation and what chromosome number is affected in portwine stain

A

GNAQ chromosome 9

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16
Q

vascular tumor in sun damage lip of elderly

with hitopath of dilated and congested vein

A

venous lake

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17
Q

vascular tumor that represents

1) ectasia of superficial capillaries that are congersted with 2 epidermal changes:
a) . acanthosis
b) hyperkeratosis

A

angiokeratoma

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18
Q

difference ng angiokeratoma and verrucous hemangioma

A

verrucous hemangioma nasa superficial and deep and dilated blood vessels and angiokeratoma ay superficial

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19
Q

syndrome related to angiokeratoma

A

anderson-fabry syndrome

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20
Q

warty blue nodule on the extremities with dilated capillaries n the whole dermis with acanthosis and hyperkeratosis

A

verrous venous malformation (don’t use verrucous hemangioma)

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21
Q

other term for arteriovenous malformation

A

cirsoid aneurysm

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22
Q

reddish blue papule less than 1 cm diameter

with histopathology of dilated thick walled BV on dermis up to subQ with plump endothelium, thick muscular walls and micro thrombi and caclification

A

arteriovenous malformation )cirsoid aneurysm

23
Q

lobules of dilated or congested capillaries surrounded by layers of pericytes. each lobules are surrounded by fibrosis with inflammation, bigger BV calcification and hemosiderin

A

RAPIFLY INVOLUTING CONGENITAL HEMANGIOMA

24
Q

STAIN OF GLUT-1 IN RICH

A

GLUT-1 NEGATIVE pero sometimesd postive sa tumor lobules

25
Q

CAUSE OF Regression in RICH

A

infarction

26
Q

histopathology of NICH

A

tumor lobules din of capillaries but sometimes Malaki young vessels sa look ng lobules

gLUT-1 negative din sya

with arteriovenous fistula din aka mo cissoid aneuryssm

27
Q

difference between development of RiCH NICH and infantile hemangioma

A

RICH - develops BEFORE birth
NICH- AT birth
infantile hemangioma- develops AFTER birth

28
Q

other term for infantile hamangioma (2)

A

strawberry nevus; juvenile hemangioma

29
Q

most important ddx of infantile hemangioma

A

RICH and NICH kazoo and strawberry nevus walling fibrosis

30
Q

most common vascular tumors of childhood

A

infantile hemangioma

31
Q

the only vascular tumor positive for. GLUT-1 and WT-1

A

infantile hemnagioma

32
Q

what is infantile hemangioma? tumor or hamrtoma?

A

hamartoma

quasi may endothelial cells, pericytes and fibroblasts

33
Q

flat red <5cm raised papule with intradermal or subq of multi lobular proliferation of small vascular spaces with plump endothelial cells with MITOSIS! with perineurial invasion

A

infantile hemangioma - clonal

34
Q

postive stains for infantile hemangioma

negative for PROX-1

A

reticulin stain- vascular channels in early bags magdilate sa late

2) GLUT-1 ; WT-1
3) LYVE-1 and CD34- sa endothelial cells that are plump. negative na sya paginvoluting stage na meaning that the endothelial cells are arrested early

35
Q

histpath of abortive hemangioma

A
  • patch - vascular channels sa superficial and then lobules of capillaries sa deep

papule shows capillary hemangioma features

36
Q

other term for cherry angioma

A

senile angioma

campbell de morgan spots

37
Q

vascular tumor that is a polypoid lesion with epidermal collarette; lobules of dilated and congested vessels in the papillary dermis

A

cherry angioma

38
Q

co-existence of of lobular capillary hemangioma

A

port wine stain or if port wine stain is treated with pulse dye

NF-1 von hippel-lindau syndrome

39
Q

3 types of pyogenic granuloma and there location

A

1) granuloma gravidarum - gingival of prey involutes after delivery
2) subcutaneous and deep dermal - upper limb
30 intravenous lobular - neck and upper ext

40
Q

exophytic lobulated dermal mass with numerous capillaries radiating with central bigger vessels in a loose edematous collagenous matrix

mitosis are common

endothelial cells are plump or bland esp in mucosa mukhang epithelia

A

lobular capillary hemangioma

41
Q

with superficial acute and chronic inflammation especially with ulcerated lesions and the adjacent epidermis is acanthoticc

kelan lang nya walang ulceration and inflammation ang PG?

A

kqpag deeper dermis ang pyogenic granuloma

42
Q

etiology of pyogenic granuloma

A

BRAF V600E and RAS

RAS/ERK

43
Q

most important differential of pyogenic granuloma

A

bacillary angiomatosis

-caused by ROchalimaea henselae

pero ito pale eosinophilic endothelium and positive for giemsa and warthog starry

44
Q

difference ng PG with angiosarc if Pareto silang may plump endothelial cells and mitotic figures

A

pg- lobular architecture

45
Q

other term for tufted angioma

A

angiolastoma of nakagawa

46
Q

presence in th dermis and subq round or oval lobes of tights knit capillaries with cresent shaped dilated lymphatic space adjacent to the lobule, surrounded din Ito ng pericytes just like strawberry nevus

with crystalline inclusion bodies

A

tufted angioma

47
Q

type of lymphocyte increased in tufted angioma

A

CD8+ - meaning cytotoxic mediated immune system

48
Q

tufted angioma stains

1) endothelial cells
2) lymphatic
3) vessel

A

1) endothelial cells- CD31 and ERG
2) lymphatic - D2-40
3) WT-1 or GLUT -1

49
Q

difference of strawberry nevus from tufted angioma

A

strawberry nevus - more extensive hanging baba and also absence of adjacent present shape lymphatic

50
Q

difference ng tufted angioma sa kaposi sarcoma

A

may cannonball and tufted and spindle shape naan and kaposi

51
Q

bluish red tumor that is a vascular malformation with proliferation of dilated blood vessels in superficial dermis with flattened endothelial cells and it is not lobular. no epidermal collarette

A

cavernous hemangioma

52
Q

variant of cavernous hemangioma with markedly dilated lobular back-to back congested vascular channels in sieve like pattern

A

sinusoidal hemangioma

53
Q

difference between sinusoidal hemangioma with angiosarc

A

as infiltrative and atypical; with mitotic figures and angiosarc

mckee dermpath (2 decks)

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