Tumor Markers Flashcards by Jenn Sternberg

Tumor Markers

Can be used to monitor tumor recurrence and response to therapy. NOT used as primary diagnosis. Must do a biopsy for that.

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Alkaline Phosphatase

Metastasis to bone/liver, Pagets

Seminoma (placental ALP)

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Alpha-fetoprotein

Normally made by fetus.
Hepatocellular carcinoma, hepatoblastoma
Yolk sac tumor
Testicular cancer
Mixed germ cell tumor

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Beta-HCG

Hyatidiform mole & choriocarcinoma
Testicular cancer
Also normal in pregnancy, obvi

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CA-15-3/CA-27-29

Breast cancer

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CA-19-9

Pancreatic adenocarcinoma

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CA-125

Ovarian cancer

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Calcitonin

Medullary thyroid carcinoma

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CEA (CarcinoEmbryonic Antigen)

Very nonspecific, but produced in 70% of colorectal & pancreatic cancers.
Gastric, breast, medullary thyroid carcinoma

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PSA (Prostate Specific Antigen)

Prostate adenocarcinoma & BPH

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S-100

Neural crest origin (melanomas, neural tumors, schwannomas, Langerhans cell hsitocytosis)

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TRAP (Tartrate-Resistant Acid Phosphatase)

Hairy cell leukemia

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Tumor Markers Flashcards

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