Oncogenes Flashcards
1
Q
BCR-ABL
A
CML, ALL
Tyrosine kinase
2
Q
bcl-2
A
Follicular and undifferentiated lymphomas
Anti-apoptotic
3
Q
BRAF
A
Melanoma
Serine/threonine kinase
4
Q
c-kit
A
Gastrointestinal stromal tumor (GIST) Cytokine receptor (for stem cell factor)
5
Q
c-myc
A
Burkitt lymphoma
Transcription factor
6
Q
HER2/neu (c-erbB2)
A
Breast, ovarian, & gastric carcinoma
Tyrosine kinase
7
Q
L-myc
A
Lung tumor
Transcription factor
8
Q
N-myc
A
Neuroblastoma
Transcription factor
9
Q
ras
A
Colon cancer, lung cancer, pancreatic cancer
GTPase
10
Q
ret
A
MEN 2a and 2b
Tyrosine kinase
11
Q
Oncogenes
A
Gain of function leads to increased cancer risk
Only need damage to 1 allele
