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CC LAB: QUIZ 2 > Tumor Markers > Flashcards

Tumor Markers Flashcards

1
Q

Used to look on melanoma spread before, during
and after treatment

A

S-100

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2
Q

a glycoprotein Oncofetal Antigen

A

Alpha-Feto protein

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3
Q

Marker of GIT CANCER

A

Carcinoembryonic Antigen

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4
Q

increase in Multiple myeloma, CLL, some lymphomas

A

Beta 2 Microglobulin

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5
Q

Abnormal levels of NSE

A

> 9ug/ml

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6
Q

Used to asses growth of cancer cells

A

HER 1

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7
Q

protein on outer melanoma cells

A

TA-90

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8
Q

for gastric & pancreatic cancer (recurrence & treatment)

A

CA 50

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9
Q

Checked along with NMP for recurrence of bladder camcer

A

Bladder Tumor Antigen

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10
Q

Metastatic Cancer of bone, Hepatocellular cancer,
Osteosarcoma, Lymphoma, Leukemia

A

Alkaline Phosphatase

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11
Q

Uses:

A
  • Diagnosing cancer
  • Treatment check
  • Testing treatments
  • Detecting recurrent cancer
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12
Q

C-peptide is measured by

A

ELISA (Enzyme linked immunosorbent Assay)

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13
Q

Most sensitive for carcinoid tumors

A

Chromogranin A

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14
Q

hormones used to detect Neuroblastoma, Pheochromocytoma,
Paranganglionoma

A

Catecholamines

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15
Q

hormone used to detect recurrent thyroid cancer

A

Thyroglobulin

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16
Q

Two types of oncofetal antigen

A

Alpha-Feto protein
Carcinoembryonic Antigen

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17
Q

hormone for Adrenal tumors

A

Cortisol

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18
Q

Now used to detect pancreatic cancer

A

CA 19-9

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19
Q

CA 19-9 NV

A

<37u/ml

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20
Q

highly specific for prostate
cancer

A

Prostate Specific Antigen

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21
Q

Method for detection of BCR-ABL

A

PCR

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22
Q

Cancer antigen for ovarian & pancreatic cancer; Also stomach cancer

A

CA 72-4

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23
Q

CA-125 Normal Value

A

<35u/ml

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24
Q

NSE is used for follow up of patients with

A

small cell lung cancer and neuroblastoma

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25
Q

Alpha-feto protein level that would Indicate Hepatic Cancer

A

> 350 ng/mL

26
Q

When to check Tumor markers:

A
  • At time of diagnosis
  • Before, during, or after treatment
  • Regularly after many years to check recurrence
27
Q

Carcinoembryonic Antigen level is increased in:

A

heavy smokers

28
Q

Serum protein that is elevated in some testicular and Ovarian cancer

A

Beta-human Chorionic Gonadotropin

29
Q

Found in all prostate cells

A

Prostate specific membrane antigen

30
Q

Prostatic acid phosphatase is also used for

A

multiple myeloma & lung cancer

31
Q

gray zone levels for PSA

A

4-10ng/ml

32
Q

Marker for Chronic Myeloid Leukemia

A

BCR-ABL

33
Q

High levels of PSMA may indicate

A
  1. Age (as you age, PSMA increases)
  2. prostate cancer
34
Q

Gene that Increases in Breast cancers, Stomach cancers

A

HER 2

35
Q

an abnormal gene

A

BCR-ABL

36
Q

CA 27.29 normal value

A

<40u/ml

37
Q

Enumerate advantages of using tumor markers

A
  • Non-invasive in nature
  • More accurate quantification
  • Lack of inter-observer difference
  • Early detection
38
Q

an enzyme which is a Marker for NEUROENDOCRINE TUMORS

A

Neuron specific Enolase

39
Q

Helps diagnose and guide the treatment of LIVER CANCER

A

Alpha-Feto protein

40
Q

used for Breast Cancer

A

CA 15-3

41
Q

Beta 2 Macroglobulin normal value

A

<2.5mg/L

42
Q

GI tract & pancreas in fetal development

A

Carcinoembryonic Antigen

43
Q

CA 15-3 Normal value

A

<30u/ml

44
Q

Increased tumor concentration =

A

increased tumor progression

45
Q

hormones for medullary-thyroid Carcinoma!

A

Calcitonin

46
Q

Thyroglobulin is measured by

A

Double antibody RIA, ELISA Immunoradiometric assay

47
Q

Serum proteins for melanoma

A

S-100
TA-90

48
Q

standard marker = Epithelial Ovarian cancer

A

CA 125

49
Q

Found in urine with Bladder cancer

A

Bladder Tumor Antigen

50
Q

Gene used in assessing colorectal cancer

A

V-ki-ras2

51
Q

Characteristics

A

-Cancer sensitive, specific
-Tissue specific
-Readily detectable in serum
and OBF
-high level in early stage
-Serum levels correlate with tumor burden

52
Q

Used to monitor treatment effect and to watch for recurrence of disease

A

Lactate dehydrogenase

53
Q

made by neuroendocrine tumors

A

Chromogranin A

54
Q

Method for detecting cancer antigens

A

Immunoassay

55
Q

Calcitonin is produced by

A

parafollicular cells of thyroid

56
Q

Serotonin is measured by

A

HPLC (High-Performance Liquid Chromatography)

57
Q

NV for Calcitonin

A

5-12pg/ml

58
Q

Serum proteins used as a marker for bladder cancer

A

Bladder Tumor Antigen
Nuclear matrix protein

59
Q

Substances that can be found in the body (blood, urine, OBF, Tissues, Tumors)
when cancer is present or monitoring the progress of cancer

A

TUMOR MARKERS

60
Q

Increased in acute and chronic hepatitis; Also increased in testicular cancers & rare types of ovarian cancer, Choriocarcinoma

A

Alpha-Feto protein

61
Q

Marker: Testicular Cancer & other germ cell tumors

A

Lactate dehydrogenase

62
Q

use to follow patients with breast cancer during or after treatment

A

CA 27.29

CC LAB: QUIZ 2 (2 decks)

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