Tumor Genes

Question 1

E-cadherin

Answer 1

Gastric carcinoma, lobular breast carcinoma

Question 2

c-MYC

Answer 2

Transcriptional activator; Burkitt lymphoma

Question 3

NF2

Answer 3

Neurofibromatosis type 2; acoustin schwannoma and meinigioma

Question 4

KRAS

Answer 4

GTP-binding proteins; Colon, lung, and pancreatic tumors

Question 5

Burkitt lymphoma

Answer 5

c-MYC 8q24/IGH 14q32 translocation

Question 6

NRAS

Answer 6

GTP-binding proteins; Melanomas, hematologic malignancies

Question 7

RET

Answer 7

Receptor for neutrophic factors; Multiple endocrine neoplasia 2A and 2B

Question 9

INK4/ARF Family

Answer 9

p16/INK4a binds to cyclin D-CDK4 and promotes inhibitory effects of RB
p14/ARF increases p53 levels by inhibiting MDM2 activity

Question 10

JAK2

Answer 10

JAK/STAT signal transduction; Myeloproliferative disorders

Question 12

CCND1 (cyclin D)

Answer 12

Cyclins; mantle cell lymphoma

Question 13

KIT

Answer 13

Receptor for KIT ligand; Gastrointestinal stromal tumors

Question 14

MEN1

Answer 14

Multiple endocrine neoplasia-1 (pituitary, parathyroid and pancreatic endocrine tumors)

Question 15

ALK

Answer 15

ALK receptor; Adenocarcinoma of lung

Question 17

NOTCH1

Answer 17

NOTCH signal transduction; Leukemias

Question 18

p53

Answer 18

tumor suppressive; causes cell cycle arrest and apoptosis

required for G1/S checkpoint and main component of G2/M checkpoint

Question 19

Chronic myelogenous leukemia

Answer 19

ABL 9q34/BCR 22q11 translocation

Question 20

NF1

Answer 20

Neurofibromatosis type 1; peripheral nerve sheath (skin tumors)

Question 21

n-MYC

Answer 21

Transcriptional activation; neuroblastoma

Question 21

l-MYC

Answer 21

Transcriptional activation; small cell carcinoma of lung

Question 22

RB

Answer 22

tumor suppressive; prevents G1/S transition

Retinoblastoma and osteosarcoma

Question 23

BRCA1/2

Answer 23

familial breast and ovarian cancers

Question 24

GNAS

Answer 24

GTP-binding proteins; Pituitary adenoma, other endocrine tumors

Question 25

PTEN

Answer 25

Cowden syndrome

Question 26

VHL

Answer 26

Von Hippel Lindau syndrome (renal cell carcinoma)

Question 27

WT1

Answer 27

Wilms Tumor

Question 28

ERBB1 (EGFR)

Answer 28

EGF-receptor family; Adenocarcinoma of lung

Question 29

ERBB2 (HER)

Answer 29

EGF-receptor family; Breast carcinoma

Question 30

CDK4; D cyclins

Answer 30

phosphorylates RB, allowing cell to progress through G1 restriction point

Question 31

Ewing sarcoma

Answer 31

FLI1 11q24/EWSR1 22q12 translocation

Question 31

TP53

Answer 31

p53 protein, Li-Fraumeni syndrome (first “hit”, diverse cancers)

Question 32

ABL

Answer 32

Nonreceptor tyrosine kinase; Chronic myeloid leukemia, Acute lymphoblastic leukemia

Question 33

BRAF

Answer 33

RAS signal induction; Melanomas

Question 33

PTCH

Answer 33

Gorlin syndrome (basal cell carcinoma)