Tubular Transport DSA Flashcards
What is the Na reabsorption stimulated by in the loop of henle?
Aldosterone
A pump that moves ions against electrochemical gradient is also called what?
electrogenic - creates charge separation and potential difference
Where are H/K ATPase found in the renal system? what can inhibit this pump?
Intercalated cells of renal collecting duct
Omeprazole
Where is the Na/AA cotransport in the renal system?
Proximal tubule
Where is the Na/K/Cl cotransporter? what can inhibit this transporter?
In the thick ascending limb
Loop diuretics
Where are Na/Cl cotransporters? what are the inhibitors?
DCT only
Natriuresis with diuresis - bensothiazides
What is the transeptithelial potential difference in the proximal tubule?
-2mV in convoluted part
+2mV in straight part
What is the transepithelial potential difference in the thick ascending limb?
Positive lumen
+6-10 mV
What is the transepithelial potential difference in the distal tubule?
Negative lumen so less anions reabsorbed bc tight junctions become tighter
-70mV
Tr =
(GFR*Px) - UxV
What are the three primary factors controlling Na reabsorbtion?
Apical Na transport
Basolateral N/K ATPase
Starling forces
What is the main driver of countercurrent multiplier system
The Na reabsorption in thick ascending limb
