Tuberculosis

Question 1

Two major categories of Agents used in treatment of TB

Answer 1

First Line : Combine the greatest level of efficacy with an acceptable of toxicity
(USED FIRST)
Second line: Microbial resistance or patient factor may indicate the use of these agents(when first line doesn’t work)

Question 2

Isoniazid

Answer 2

Primary drug for TB
Bactericidal for dividing bacteria
Bacteriostatic for resting bacteria
Metabolized by adding acetyl groups
Slow acetylation longer half life ~ 3 hours
Fast acetylation shorter half life ~ 70 mins

Question 3

Rifampin

Answer 3

Inhibit the bacteria protein synthesis

Used for TB

Question 4

Pyrazinamide

Answer 4

Bacterial cidal

interacts with liver enzymes

Question 5

Ethambutol

Answer 5

Inhibits the corporation of mycolic acid into the mycobacteria
Optic neuritis, red and green distinction

Question 6

Streptomycin

Answer 6

First line agent
Belongs to Aminoglycides
Neuro and ototoxic

Question 7

Aminosalicyclic Acid

Answer 7

Secondary drug
Prevents Folic Acid
Dependent on G6P dehydrogenase, will lead to hemolytic anemia

Question 8

Ethionamide

Answer 8

Secondary drug

Hepatitis 5% cases

Question 9

Cycloserine

Answer 9

Secondary agent

Cell wall inhibitor

Question 10

Artemisin

Answer 10

Used in Maleria

Does not relay on G6P