Truelearn Advanced Flashcards
Sodium bicarbonate added to local anesthetic decreases pain and increases onset due to
More unionized fraction due to higher pH so more ions pass through unionized cytoplasmic membrane faster
Using Succ or volatile anesthetic in patient with Becker’s muscular dystrophy/or chill vac’s can lead to
Rhabdomyolysis
Can lead to rapid hyperkalemia formation which leads to wide qrs and then v fib
Absolute contraindications to ECT
Intracranial mass lesion
Pheo
Unstable cervical spine
Recent MI within 4-6 weeks
Pregnancy is a relative contraindication
MH has higher
ETC02 and muscle rigidity and temp increas than thyroid storm
Veins arterioles more stiff
As you age and less compliant. Leads to high SVR and LV hypertrophy
Dobutamine on elderly causes
Tachycardia/ reduced diastolic filling time and some increase in contractility leading to decreased end diastolic volume and ultimately decreased cardiac output
Posterior fossa surgery best way to monitor brain stem ischemia
Auditory evoked potentials
Opioids usually don’t affect evoked potentials
Don’t
Apnea brain death test
No spontaneous breath up to pac02 of 60
After thigh tourniquet release
End tidal co2 increases transiently
Distal tissues go from aerobic to anaerobic metabolism
Severe drop in ETC02 after tourniquet release think
PE
SVR is increased in obstructive shock to help with
Low cardiac output state
Distributive shock
Spinal cord injury leading to neurogenic shock
Biggest predictor is a loss of SVR
In hypovolemic shock SVR up
Volatile anesthetics least affect
Brainstem auditory evoked potentials
Need to evaluate SSEPs for
Spine surgery
Management of hypermagnesium
It is renally excreted so more likely in patients with renal disease
5-9 mg/dL normal range for preeclampsia patients
Depresses cardiac muscle contractility and function
Don’t give theophylline to treat
Treatment includes calcium, dialysis, loop diuretic plus saline
It prolongs succ and potentiates NMDBs(makes them work longer)
Nerve regeneration after cryoanalgesia takes
1-3 months
Opioid only regional anesthesia can’t be used for cystoscopy in patient with spinal cord transection
Still get autonomic hyperreflexia
AH
Acute hypertension, reflex bradycardia, cardiac arrhythmias, MI, pallor, coolness is lower extremity, sweating in upper extremity
Starts 2 to 6 weeks after surgery
Get Vasodilation above and vasoconstriction below
Volatile inhalational induction faster in infants due to
Greater fraction of cardiac output to the vessel rich group
Phrenic nerve stimulators are used to improve
Atelectasis
Hypotension decreases
Uterine perfusion.
Partial bilateral RLN injury
Complete obstruction
Get unopposed adduction
With complete it affects both abduction and adduction so stay in a para median position
ECT causes an increase in
ICP and cerebral blood flow which is of concern to patients with space occupying lesions
During ECT can see
Bradycardia tachycardia and short term memory loss
To reverse in pregnant patient with neostigmine use
Atropine bc glycopyrolate doesn’t cross BBB
Vasodilation occurs with magnesium therapy and can
Lower BP
Mag competes with calcium inside vascular smooth muscle cells
Mag inhibits
Voltage gated calcium channels
Don’t add potassium to maintenance fluid until you have good
Urine output
Pyloric stenosis high risk for
Postop apnea due to alterations in CSF ph and central chemoreceptor response to C02, therefore minimize opioid use and hyperventilating
No shivering thermogenesis in infants from
Norepinephrine, glucocorticoid, and thyroxine
Inhibited by inhalational anesthetics and beta blockers
Successful stellate ganglion block
Temporary sympathectimy to face and eye
Stellate ganglion block can lead to inability to sweat and flushed skin
ARDS more Fi02
Doesn’t help bc they are shunting leading to hypoxemia
ECMO bypasses the lungs and can help with
Gas exchange in ARDS
To anesthetize the lateral forearm need to get
Choracobrachialis muscle to anesthetize the musculocutaneous nerve
Syringomyelia
Causes central cord syndrome with maintenance of proprioception, touch and vibration and plus loss of pain and temperature sensation
Associated with Chiaari 1 and trauma
Fluid filled cyst in center of spinal cord
Diminished sweating with
Autonomic neuropathy
When anemia was present
An improvement in clot strength and quality was seen
Low biphasic waveform defibrillation has more success than
Monophasic waveform defibrillation
Longer the patient has had an arrhythmia the more difficult it is to defibrillate
Want 12cm electrodes
Plasma half life of methadone
13 to 50 hours but analgesic affect is 4-8 hours
For ESRD lower methadone dose 50%
Methadone
Mu receptor agonist
NMDA antagonist
MAO reuptake inhibitor
Methadone black box warning
Death from respiratory depression
Cardiac effects
Arrhythmias like torsades
Congenital emphysema do not give
Nitrous oxide
For a bleb don’t give positive pressure as it may increase the size or rupture the bleb. Use spontaneous ventilation
Botox works by
Inhibition of intracellular fusion of Ach containing vesicles
Not inhibition of bonding of AcH to receptor
Toxin only affects exocytosis thus the release of Ach going into the membrane thus those Ach molecules never reach the receptor
To avoid Dural puncture headache use
Smallest(27 gauge) non cutting needle
Risk factors for PDPH
Young age
Pregnant
Hx headaches
Large bore cutting needle
To improve pulmonary artery flow during a tet spell
Increase SVR with phenylephrine
Increase PVR shunts blood through vsd. SVR becomes less than PVR and blood goes to path of least resistance.
Phenylephrine increases SVR thus increasing pulmonary blood flow and reflex brady decreases hypercontractility
Intrascalene blocks commonly cause ipsilateral
Horners syndrome which includes ptsois, miosis, and Anhydrosis
Good for upper arm/shoulder surgery
Be careful doing intrascalene on patient with preexisting lung disease
Can hit phrenic leading to ipsilateral diaphragmatic paralysis which can lead to respiratory failure
MS patients have respiratory muscle weakness leading to
Aspiration, pneumonia, or acute respiratory failure
Loss of fetal heart rate variability is an early sign of
Fetal hypoxia
Magnesium potentiates the action of both
NMDB and depolarizing muscle relaxants
Give same dose of succ for intubation but lower dosage of rocuronium
Early decelerations occur
Simultaneously with uterine contractions
Late decelerations lag 10-30 seconds past uterine contractions
Treatment of choice for surgical bleeding prophylaxis in patients with VWD is
Desmopressin
Volume of aspiration and pH<2.5 major risk factors for
Pneumonitis
Increasing pH reduces risk of aspiration pneumonitis
After what week of pregnancy high risk of aspiration
18th
Delay emptying with opioids
Neuraxial and parenteral
Avoid hypotonic fluids on
Traumatic brain injury
Goal is to maintain CPP
50-70
CO causes endothelial cells and platelets for release
Nitric oxide
High NG output increases
SID and therefore causes alkalosis
Decrease SID
Lowers pH leading to acidosis
Children have slower redistribution of heat from core to
Periphery
Greatest heat loss comes from
Radiation
Shivering can increase oxygen consumption
A lot
C diff toxin enzyme immunoassay if concern for
C diff
Thyroid storm
Hyperthermia, tachycardia, agitation and confusion
CDH
Low tidal volume
PIP<25
Preductal sat want 90-95%
Low medial Thigh nerve root
L3
Best way to monitor RLN injury during thyroid surgery
EMG
Nasal CPAP has lowered BPD when compared to
Intubation and ventilation in neonates
Hypophosphatemia
Dysfunction of skeletal muscle
Hyperphos
Prolonged qt
Increased hemoglobin
More oxygen delivery
If someone is on high ventilatory support need another
Confirmatory death test bc apnea test inaccurate
SAH greater admission hgb decreased incidence of
Cerebral infarction
Vasospasm during SAH peaks at
5-7 days
Chronic renal insuffiency
Not an independent risk factor for compartment syndrome
Laparoscopic surgery is
Obturator nerve block goes between adductor
Longus and brevis
Obturator is not a branch of the
Femoral nerve
Quickest way to lower ICP transiently is a
Propofol bolus
Head up position
Diuretics maintain map drain csf
Bradycardia following carotid stent deployment
Carotid sinus baroceptor stimulation causing sympathetic inhibition
Carotid body senses
Pa02 and increases ventilation if hypoxia
Most effective treatment for refractory hypotension causes by AceI is
Norepinephrine not vasopressin
Massive venous air embolus cardiovascular collapse due to
RVOT obstruction resulting from air lock phenomenon in RV
Determining who is responsible for an event is not an endpoint of
Root cause analysis
Hyperbaric oxygen therapy works by
Increasing Pa02 and thus the amount of dissolved oxygen
Pyloromyotomy
Normalization of chloride most important metabolic change suggesting surgical optimization
Diaphragm is too anterior in intrascalene hitting phrenic so move needle more
Posterior
If sartoriius twitches during femoral block move needle more
Lateral
Most common congenital anomaly recognized at birth
Perimembranous VSD
PDA
Continuous machine like murmur at upper left sternal border
Organophosphate poisoning treat with
Atropine
After hemodialysis patients can get
Hypokalemia
ESRD patients have
Anemia not polycythemia
Supraclavicular block is next to the
Subclavian artery
Patient with chronic alcohol use have
Hypomagnesium
Glucose loading during TPN leads to
Hypophosphatemia
Patient should be monitored how long after raceemic epinephrine
4-5 hours at least
ESI has high success rate for providing
Short term analgesia for acute radicular pain due to disk herniation or spinal stenosis with nerve impingement
Epinephrine is not
Metabolized in the lungs or while in the pulmonary circulation
Would have skin pallor in lower
Extremities not flushing
Autonomic hyperreflexia shows up
2 weeks to 6 months after spinal cord injury
Do not use naloxone on neonatal resuscitation even if mother received large dose of
Morphine and is a drug user
Max lidocaine with epi dose is
7 mg/kg
1% lidocaine is 10mg per ml
Thoracic aortic aneurysms repair give
Fenoldopam which increases renal blood flow
Naturesis
Urine sodium excretion
Fenoldopam increases intraocular pressure so be careful using in a patient
With glaucoma or intraocular HTN
Radiation induced injury to thyroid via nuclear event can use
Potassium iodide
Peak and plateau pressure big difference usually due to
Kinking of endotracheal tube
Lupus anticoagulant prolongs activates PTT but not prothrombin time
PT
Factor 7 requires
Vitamin K for synthesis
Cryoprecipitate contains
Fibrinogen, fibronectin, VwF, and factors 8 and 13
Hypothermia decreases the metabolic rate of the
Brain.
During DHCA blood flow is
Non existent
Hypothermia is most important factor to decrease
Cerebral ischemia
Patients with hypoplastic left heart have Ductal dependent
From pda from RV to pulmonary artery
Pulmonary blood flow increase increases Qp to Qs then can get systemic hypoperfusion
If Fi02 goes up get reversal off hypoxia pulmonary vasoconstriction and decrease in PVR so pulmonary blood flow goes up resulting in systemic hypoperfusion
Decrease minute ventilation increases
PVR
Hypoplastic heart
First Norwood to Glenn to fontan
Bupivicaine highly protein bound so less
Placental transfer
If pKA higher than pH it will be
Ionized
2-4 days after being in altitude see
Bicarbonate loss in the CSF
Femoral and sciatic supply the knee
Can do knee replacement with
Lumbar epidural
Breast milk leads to higher gastric volumes than clears this is why it is
4 hours vs 2
NPO guidelines are based on gastric residual volumes
Cryoprecipitate does not contain factor
7
Neonates when cold use
Non shivering thermogenesis(oxidation of brown fat)
Increases glucose consumption and increases likelihood of hypoglycemia
Primary hyperaldosterone treat with
Spirnolactone
Transcutaneous pacers first activate the
Right ventricle similar to a VOO mode
Skeletal muscle can hurt when doing transcutaneous pacing so should give some
Sedation
Asymmetric LVH in
Hypertrophic cardiomyopathy
Avoid tachycardia, increased myocardial contractility, decreased diastolic filling time
Brain death can occur without
Herniation
Edema during brain injury becomes both
Vasogenic and cytotoxic
MG<72 months less likely for
Postop intubation
Also less likely if viral capacity is greater then 3
Redirect needle medial if
Foot eversion twitch is seen
Foot eversion twitch means you hit the common peroneal
Need to redirect needle more medial
Tibial nerve
Plantarflexion
.5 mg/kg oral versed for
Peds
Give 10 minutes before
Seperation anxiety starts at 6 mo
Suggamadex is ok on patients with
CHF
Not fda approved on pediatric patients
Patients with severe renal failure
Reversal of other nmbds besides roc or vec
Epiglottis management
Direct laryngoscopy under deep general anesthesia
Cyanide toxicity
Elevated anion gap
Cyanide toxicity
Oxygen is present so Pa02 will increase and oxygen can’t be utilized so Sv02 will increase
Chronic pelvic pain
Superior hypogastric
Methadone good for patients with
Chronic neuropathic pain
Why does maternal blood volume go up in pregnancy
Sodium retention via renin angiotensinogen system
Lumbar plexus block spares the
Sciatic nerve
LPB
Patient in lateral decubitus
Hit L4 transverse process
Then go cephalad until it slides past transverse process 2 cm deeper
Sciatic nerve
L4-S3
Patients with myasthenic syndrome
More sensitive to depolarizing and nondepolarizin blockers
Omphalocele
Chromosomal abnormalities
Cardiac resync therapy for
LVEf less then or equal to 35
IV conduction delay greater than 120msec
Cardiac myoxomas mainly found in the
Left atrium
Unstable patient with torsades
Unsynchronized cardioversion
Use a short duration stimulus when doing
Sciatic nerve block
Acute stretching of peritoneum can lead to
Asystole in laparoscopic procedures
Perforation ileofemoral axis during transcatheter aortic valve replacement
Hypotension and retroperitoneal extravasation
No lipid anabolism during
Stress response. You do see protein anabolism/catabolism
Most important for uterin blood flow is
Blood pressure
Zenker diverticulum absolute contraindication to
TEE placement
Don’t give what med with ECT
Lidocaine
Midazolam bioavailability
Intramuscular>intranasal>rectal>oral
Measuring oximetry in patient with lvad with
Oximitrey cerebral
Motor potentials
MEPs for anterior spinal cord
Patients with severe lung disease have least response to
Bronchodilator therapy
What nerve can get injured during repair of a PDA
Recurrent laryngeal nerve
Early onset adult ventilator pneumonia is likely due to
MSSA
Adding PEEP increases
FRC
Decreasing I to E ratio can help with
Breath stacking
Spinal cord stimulator directly affects
Dorsal horn of spinal cord and prevents conduction of chronic pain sensation
Spinothalamic tract the neurons cross to
Contra lateral side of spinal cord via anterior white commissure
Hypoalbumin will increase free fraction of benzos thus
Lower amounts can be given
Resistance to NMDBs starts 1 week following burn and peaks at
5-6 weeks
MEPs monitor
Anterior spinal cord
EEG monitors the
Cortex only
During hemodialysis large proteins don’t pass through so get increase in
Prealbumin levels
Factors 11 13 tpa and antithrombin 3
Decrease during pregnancy
Gabapentin is alpha 2 with
Very little respiratory of cardiac complications
Intrascalene May miss C8-T1 so don’t get
Ulnar
Best way to prevent post kidney transplant injury is
Good intravascular volume this is why we give mannitol before releasing vascular clamps
Cryoprecipitate contains
Factor 8 and fibrinogen(factor 1)
Methylergonive
Lasts 2-4 hours and given intramuscular
Hyperthyroidism
Decrease SVR
Looks like septic state
Insulin requirements go down after
Delivery
Leads to fetal macrosomia due to more glucose
Tachycardia
Less time in diastole and use more myocardial oxygen which is bad
Overriding aorta gets blood from
LV and RV
Avoid hypotension and increases in PVR
With primary P HTN
Chronic opioid use leads to
Decreased cortisol levels
Sodium deficit
140-serum sodium * total body water(.6)
Dantrolene contains
Mannitol
Oral versed
0.5 mg/kg in peds
Acts in 15-30 minutes
Salicylate poisoning
Metabolic acidosis and respiratory alkalosis
Trigger point injections
Do for painful limited range of motion
Oculocardiac reflex
Trigeminal and vagus nerve
Nd Yag laser passes
Through cornea without damaging it
Nd yag protective lens is
Green
C02 is clear plastic
Fetal tach
Maternal hyperglycemia
Maternal tachycardia
Terbutaline
Anterior cervical spine surgery can lead to vocal cord palsy due to endotracheal tube cuff on
RLN so need to readjust cuff once exposure happens
Trendelenberg decrease in
ERV and RV
Meperidine blunts
Shivering response to hypothermia which reduces total body oxygen demand
Goal temp
32 to 36 out of hospital cardiac arrest
Fasting cooling is endovascular cooling
Airway work of breathing in infants higher due to
Highly compliant chest wall
Catecholamine levels are much higher in
Geriatric patients
Myofascial pain syndrome
Trigger points in skeletal muscle often secondary to overuse and trauma
Will cause non dermatome pattern of radiation when palpated
Wait
6 hours after subq heparin to do epidural
In Addison’s disease you see
Hypercalcemia
SVT with wolf Parkinson’s white
Procainamide
Labetalol is more
Beta than alpha
iN0 can result in methemoglobinemia resulting in a
Left shift of the oxyhemoglobin curve and a decrease in the P50
High spinal blockade
Give fluid bolus and phenylephrine infusion but still endorses nausea what do we give
Atropine
Less pain
Less catecholamine release
Hyperparathyroidism can cause hyperchloremia
Increases renal bicarbonate loss, which may result in a normal anion gap metabolic acidosis
Multiple myeloma is associated with
Anemia not polycythemia
If in steep trendelenberg
Minimize laryngeal and facial edema
Avoid what drug in a pheo case
Ketamine
Remifentanyl is broken down by
Red blood cell and tissue esterases
Full term newborn
80-90 ml/kg
Premature blood volume
90-105 ml/kg