Truelearn Advanced Flashcards
Sodium bicarbonate added to local anesthetic decreases pain and increases onset due to
More unionized fraction due to higher pH so more ions pass through unionized cytoplasmic membrane faster
Using Succ or volatile anesthetic in patient with Becker’s muscular dystrophy/or chill vac’s can lead to
Rhabdomyolysis
Can lead to rapid hyperkalemia formation which leads to wide qrs and then v fib
Absolute contraindications to ECT
Intracranial mass lesion
Pheo
Unstable cervical spine
Recent MI within 4-6 weeks
Pregnancy is a relative contraindication
MH has higher
ETC02 and muscle rigidity and temp increas than thyroid storm
Veins arterioles more stiff
As you age and less compliant. Leads to high SVR and LV hypertrophy
Dobutamine on elderly causes
Tachycardia/ reduced diastolic filling time and some increase in contractility leading to decreased end diastolic volume and ultimately decreased cardiac output
Posterior fossa surgery best way to monitor brain stem ischemia
Auditory evoked potentials
Opioids usually don’t affect evoked potentials
Don’t
Apnea brain death test
No spontaneous breath up to pac02 of 60
After thigh tourniquet release
End tidal co2 increases transiently
Distal tissues go from aerobic to anaerobic metabolism
Severe drop in ETC02 after tourniquet release think
PE
SVR is increased in obstructive shock to help with
Low cardiac output state
Distributive shock
Spinal cord injury leading to neurogenic shock
Biggest predictor is a loss of SVR
In hypovolemic shock SVR up
Volatile anesthetics least affect
Brainstem auditory evoked potentials
Need to evaluate SSEPs for
Spine surgery
Management of hypermagnesium
It is renally excreted so more likely in patients with renal disease
5-9 mg/dL normal range for preeclampsia patients
Depresses cardiac muscle contractility and function
Don’t give theophylline to treat
Treatment includes calcium, dialysis, loop diuretic plus saline
It prolongs succ and potentiates NMDBs(makes them work longer)
Nerve regeneration after cryoanalgesia takes
1-3 months
Opioid only regional anesthesia can’t be used for cystoscopy in patient with spinal cord transection
Still get autonomic hyperreflexia
AH
Acute hypertension, reflex bradycardia, cardiac arrhythmias, MI, pallor, coolness is lower extremity, sweating in upper extremity
Starts 2 to 6 weeks after surgery
Get Vasodilation above and vasoconstriction below
Volatile inhalational induction faster in infants due to
Greater fraction of cardiac output to the vessel rich group
Phrenic nerve stimulators are used to improve
Atelectasis
Hypotension decreases
Uterine perfusion.
Partial bilateral RLN injury
Complete obstruction
Get unopposed adduction
With complete it affects both abduction and adduction so stay in a para median position
ECT causes an increase in
ICP and cerebral blood flow which is of concern to patients with space occupying lesions
During ECT can see
Bradycardia tachycardia and short term memory loss
To reverse in pregnant patient with neostigmine use
Atropine bc glycopyrolate doesn’t cross BBB
Vasodilation occurs with magnesium therapy and can
Lower BP
Mag competes with calcium inside vascular smooth muscle cells
Mag inhibits
Voltage gated calcium channels
Don’t add potassium to maintenance fluid until you have good
Urine output
Pyloric stenosis high risk for
Postop apnea due to alterations in CSF ph and central chemoreceptor response to C02, therefore minimize opioid use and hyperventilating
No shivering thermogenesis in infants from
Norepinephrine, glucocorticoid, and thyroxine
Inhibited by inhalational anesthetics and beta blockers
Successful stellate ganglion block
Temporary sympathectimy to face and eye
Stellate ganglion block can lead to inability to sweat and flushed skin
ARDS more Fi02
Doesn’t help bc they are shunting leading to hypoxemia
ECMO bypasses the lungs and can help with
Gas exchange in ARDS
To anesthetize the lateral forearm need to get
Choracobrachialis muscle to anesthetize the musculocutaneous nerve
Syringomyelia
Causes central cord syndrome with maintenance of proprioception, touch and vibration and plus loss of pain and temperature sensation
Associated with Chiaari 1 and trauma
Fluid filled cyst in center of spinal cord
Diminished sweating with
Autonomic neuropathy
When anemia was present
An improvement in clot strength and quality was seen
Low biphasic waveform defibrillation has more success than
Monophasic waveform defibrillation
Longer the patient has had an arrhythmia the more difficult it is to defibrillate
Want 12cm electrodes
Plasma half life of methadone
13 to 50 hours but analgesic affect is 4-8 hours
For ESRD lower methadone dose 50%
Methadone
Mu receptor agonist
NMDA antagonist
MAO reuptake inhibitor
Methadone black box warning
Death from respiratory depression
Cardiac effects
Arrhythmias like torsades
Congenital emphysema do not give
Nitrous oxide
For a bleb don’t give positive pressure as it may increase the size or rupture the bleb. Use spontaneous ventilation
Botox works by
Inhibition of intracellular fusion of Ach containing vesicles
Not inhibition of bonding of AcH to receptor
Toxin only affects exocytosis thus the release of Ach going into the membrane thus those Ach molecules never reach the receptor
To avoid Dural puncture headache use
Smallest(27 gauge) non cutting needle
Risk factors for PDPH
Young age
Pregnant
Hx headaches
Large bore cutting needle
To improve pulmonary artery flow during a tet spell
Increase SVR with phenylephrine
Increase PVR shunts blood through vsd. SVR becomes less than PVR and blood goes to path of least resistance.
Phenylephrine increases SVR thus increasing pulmonary blood flow and reflex brady decreases hypercontractility
Intrascalene blocks commonly cause ipsilateral
Horners syndrome which includes ptsois, miosis, and Anhydrosis
Good for upper arm/shoulder surgery
Be careful doing intrascalene on patient with preexisting lung disease
Can hit phrenic leading to ipsilateral diaphragmatic paralysis which can lead to respiratory failure
MS patients have respiratory muscle weakness leading to
Aspiration, pneumonia, or acute respiratory failure
Loss of fetal heart rate variability is an early sign of
Fetal hypoxia
Magnesium potentiates the action of both
NMDB and depolarizing muscle relaxants
Give same dose of succ for intubation but lower dosage of rocuronium
Early decelerations occur
Simultaneously with uterine contractions
Late decelerations lag 10-30 seconds past uterine contractions
Treatment of choice for surgical bleeding prophylaxis in patients with VWD is
Desmopressin
Volume of aspiration and pH<2.5 major risk factors for
Pneumonitis
Increasing pH reduces risk of aspiration pneumonitis
After what week of pregnancy high risk of aspiration
18th
Delay emptying with opioids
Neuraxial and parenteral
Avoid hypotonic fluids on
Traumatic brain injury
Goal is to maintain CPP
50-70
CO causes endothelial cells and platelets for release
Nitric oxide
High NG output increases
SID and therefore causes alkalosis
Decrease SID
Lowers pH leading to acidosis
Children have slower redistribution of heat from core to
Periphery
Greatest heat loss comes from
Radiation
Shivering can increase oxygen consumption
A lot
C diff toxin enzyme immunoassay if concern for
C diff
Thyroid storm
Hyperthermia, tachycardia, agitation and confusion
CDH
Low tidal volume
PIP<25
Preductal sat want 90-95%
Low medial Thigh nerve root
L3
Best way to monitor RLN injury during thyroid surgery
EMG
Nasal CPAP has lowered BPD when compared to
Intubation and ventilation in neonates
Hypophosphatemia
Dysfunction of skeletal muscle
Hyperphos
Prolonged qt
Increased hemoglobin
More oxygen delivery
If someone is on high ventilatory support need another
Confirmatory death test bc apnea test inaccurate
SAH greater admission hgb decreased incidence of
Cerebral infarction
Vasospasm during SAH peaks at
5-7 days
Chronic renal insuffiency
Not an independent risk factor for compartment syndrome
Laparoscopic surgery is
Obturator nerve block goes between adductor
Longus and brevis
Obturator is not a branch of the
Femoral nerve
Quickest way to lower ICP transiently is a
Propofol bolus
Head up position
Diuretics maintain map drain csf
Bradycardia following carotid stent deployment
Carotid sinus baroceptor stimulation causing sympathetic inhibition
Carotid body senses
Pa02 and increases ventilation if hypoxia
Most effective treatment for refractory hypotension causes by AceI is
Norepinephrine not vasopressin
Massive venous air embolus cardiovascular collapse due to
RVOT obstruction resulting from air lock phenomenon in RV
Determining who is responsible for an event is not an endpoint of
Root cause analysis
Hyperbaric oxygen therapy works by
Increasing Pa02 and thus the amount of dissolved oxygen
Pyloromyotomy
Normalization of chloride most important metabolic change suggesting surgical optimization
Diaphragm is too anterior in intrascalene hitting phrenic so move needle more
Posterior
If sartoriius twitches during femoral block move needle more
Lateral
Most common congenital anomaly recognized at birth
Perimembranous VSD
PDA
Continuous machine like murmur at upper left sternal border
Organophosphate poisoning treat with
Atropine
After hemodialysis patients can get
Hypokalemia
ESRD patients have
Anemia not polycythemia
Supraclavicular block is next to the
Subclavian artery
Patient with chronic alcohol use have
Hypomagnesium
Glucose loading during TPN leads to
Hypophosphatemia
Patient should be monitored how long after raceemic epinephrine
4-5 hours at least
ESI has high success rate for providing
Short term analgesia for acute radicular pain due to disk herniation or spinal stenosis with nerve impingement
Epinephrine is not
Metabolized in the lungs or while in the pulmonary circulation
Would have skin pallor in lower
Extremities not flushing
Autonomic hyperreflexia shows up
2 weeks to 6 months after spinal cord injury
Do not use naloxone on neonatal resuscitation even if mother received large dose of
Morphine and is a drug user
Max lidocaine with epi dose is
7 mg/kg
1% lidocaine is 10mg per ml
Thoracic aortic aneurysms repair give
Fenoldopam which increases renal blood flow
Naturesis
Urine sodium excretion
Fenoldopam increases intraocular pressure so be careful using in a patient
With glaucoma or intraocular HTN
Radiation induced injury to thyroid via nuclear event can use
Potassium iodide
Peak and plateau pressure big difference usually due to
Kinking of endotracheal tube
Lupus anticoagulant prolongs activates PTT but not prothrombin time
PT
Factor 7 requires
Vitamin K for synthesis
Cryoprecipitate contains
Fibrinogen, fibronectin, VwF, and factors 8 and 13
Hypothermia decreases the metabolic rate of the
Brain.
During DHCA blood flow is
Non existent
Hypothermia is most important factor to decrease
Cerebral ischemia
Patients with hypoplastic left heart have Ductal dependent
From pda from RV to pulmonary artery
Pulmonary blood flow increase increases Qp to Qs then can get systemic hypoperfusion
If Fi02 goes up get reversal off hypoxia pulmonary vasoconstriction and decrease in PVR so pulmonary blood flow goes up resulting in systemic hypoperfusion
Decrease minute ventilation increases
PVR
Hypoplastic heart
First Norwood to Glenn to fontan
Bupivicaine highly protein bound so less
Placental transfer
If pKA higher than pH it will be
Ionized
2-4 days after being in altitude see
Bicarbonate loss in the CSF
Femoral and sciatic supply the knee
Can do knee replacement with
Lumbar epidural
Breast milk leads to higher gastric volumes than clears this is why it is
4 hours vs 2
NPO guidelines are based on gastric residual volumes
Cryoprecipitate does not contain factor
7
Neonates when cold use
Non shivering thermogenesis(oxidation of brown fat)
Increases glucose consumption and increases likelihood of hypoglycemia
Primary hyperaldosterone treat with
Spirnolactone
Transcutaneous pacers first activate the
Right ventricle similar to a VOO mode
Skeletal muscle can hurt when doing transcutaneous pacing so should give some
Sedation
Asymmetric LVH in
Hypertrophic cardiomyopathy
Avoid tachycardia, increased myocardial contractility, decreased diastolic filling time
Brain death can occur without
Herniation
Edema during brain injury becomes both
Vasogenic and cytotoxic
MG<72 months less likely for
Postop intubation
Also less likely if viral capacity is greater then 3
Redirect needle medial if
Foot eversion twitch is seen
Foot eversion twitch means you hit the common peroneal
Need to redirect needle more medial
Tibial nerve
Plantarflexion
.5 mg/kg oral versed for
Peds
Give 10 minutes before
Seperation anxiety starts at 6 mo
Suggamadex is ok on patients with
CHF
Not fda approved on pediatric patients
Patients with severe renal failure
Reversal of other nmbds besides roc or vec
Epiglottis management
Direct laryngoscopy under deep general anesthesia
Cyanide toxicity
Elevated anion gap
Cyanide toxicity
Oxygen is present so Pa02 will increase and oxygen can’t be utilized so Sv02 will increase
Chronic pelvic pain
Superior hypogastric
Methadone good for patients with
Chronic neuropathic pain
Why does maternal blood volume go up in pregnancy
Sodium retention via renin angiotensinogen system
Lumbar plexus block spares the
Sciatic nerve
LPB
Patient in lateral decubitus
Hit L4 transverse process
Then go cephalad until it slides past transverse process 2 cm deeper
Sciatic nerve
L4-S3
Patients with myasthenic syndrome
More sensitive to depolarizing and nondepolarizin blockers
Omphalocele
Chromosomal abnormalities
Cardiac resync therapy for
LVEf less then or equal to 35
IV conduction delay greater than 120msec
Cardiac myoxomas mainly found in the
Left atrium
Unstable patient with torsades
Unsynchronized cardioversion
Use a short duration stimulus when doing
Sciatic nerve block
Acute stretching of peritoneum can lead to
Asystole in laparoscopic procedures
Perforation ileofemoral axis during transcatheter aortic valve replacement
Hypotension and retroperitoneal extravasation
No lipid anabolism during
Stress response. You do see protein anabolism/catabolism
Most important for uterin blood flow is
Blood pressure
Zenker diverticulum absolute contraindication to
TEE placement
Don’t give what med with ECT
Lidocaine
Midazolam bioavailability
Intramuscular>intranasal>rectal>oral
Measuring oximetry in patient with lvad with
Oximitrey cerebral
Motor potentials
MEPs for anterior spinal cord
Patients with severe lung disease have least response to
Bronchodilator therapy
What nerve can get injured during repair of a PDA
Recurrent laryngeal nerve
Early onset adult ventilator pneumonia is likely due to
MSSA
Adding PEEP increases
FRC
Decreasing I to E ratio can help with
Breath stacking
Spinal cord stimulator directly affects
Dorsal horn of spinal cord and prevents conduction of chronic pain sensation
Spinothalamic tract the neurons cross to
Contra lateral side of spinal cord via anterior white commissure
Hypoalbumin will increase free fraction of benzos thus
Lower amounts can be given
Resistance to NMDBs starts 1 week following burn and peaks at
5-6 weeks
MEPs monitor
Anterior spinal cord
EEG monitors the
Cortex only
During hemodialysis large proteins don’t pass through so get increase in
Prealbumin levels
Factors 11 13 tpa and antithrombin 3
Decrease during pregnancy
Gabapentin is alpha 2 with
Very little respiratory of cardiac complications
Intrascalene May miss C8-T1 so don’t get
Ulnar
Best way to prevent post kidney transplant injury is
Good intravascular volume this is why we give mannitol before releasing vascular clamps
Cryoprecipitate contains
Factor 8 and fibrinogen(factor 1)
Methylergonive
Lasts 2-4 hours and given intramuscular
Hyperthyroidism
Decrease SVR
Looks like septic state
Insulin requirements go down after
Delivery
Leads to fetal macrosomia due to more glucose
Tachycardia
Less time in diastole and use more myocardial oxygen which is bad
Overriding aorta gets blood from
LV and RV
Avoid hypotension and increases in PVR
With primary P HTN
Chronic opioid use leads to
Decreased cortisol levels
Sodium deficit
140-serum sodium * total body water(.6)
Dantrolene contains
Mannitol
Oral versed
0.5 mg/kg in peds
Acts in 15-30 minutes
Salicylate poisoning
Metabolic acidosis and respiratory alkalosis
Trigger point injections
Do for painful limited range of motion
Oculocardiac reflex
Trigeminal and vagus nerve
Nd Yag laser passes
Through cornea without damaging it
Nd yag protective lens is
Green
C02 is clear plastic
Fetal tach
Maternal hyperglycemia
Maternal tachycardia
Terbutaline
Anterior cervical spine surgery can lead to vocal cord palsy due to endotracheal tube cuff on
RLN so need to readjust cuff once exposure happens
Trendelenberg decrease in
ERV and RV
Meperidine blunts
Shivering response to hypothermia which reduces total body oxygen demand
Goal temp
32 to 36 out of hospital cardiac arrest
Fasting cooling is endovascular cooling
Airway work of breathing in infants higher due to
Highly compliant chest wall
Catecholamine levels are much higher in
Geriatric patients
Myofascial pain syndrome
Trigger points in skeletal muscle often secondary to overuse and trauma
Will cause non dermatome pattern of radiation when palpated
Wait
6 hours after subq heparin to do epidural
In Addison’s disease you see
Hypercalcemia
SVT with wolf Parkinson’s white
Procainamide
Labetalol is more
Beta than alpha
iN0 can result in methemoglobinemia resulting in a
Left shift of the oxyhemoglobin curve and a decrease in the P50
High spinal blockade
Give fluid bolus and phenylephrine infusion but still endorses nausea what do we give
Atropine
Less pain
Less catecholamine release
Hyperparathyroidism can cause hyperchloremia
Increases renal bicarbonate loss, which may result in a normal anion gap metabolic acidosis
Multiple myeloma is associated with
Anemia not polycythemia
If in steep trendelenberg
Minimize laryngeal and facial edema
Avoid what drug in a pheo case
Ketamine
Remifentanyl is broken down by
Red blood cell and tissue esterases
Full term newborn
80-90 ml/kg
Premature blood volume
90-105 ml/kg
Tetanus acts by
Inhibition of neurotransmitter release from inhibitory neurons in the can
Diptheria
Inhibition of elongation factor 2
In MG leading factor for postop respiratory failure is
The inability to clear secretions and produce a strong cough
P50 of fetal hemoglobin is
Lower bc it is shifted to the left
Wife complex SVT
Synchronized cardioversion
Retained epidural catheter best is to do a
CT scan
Cricoid pressure decreases
LES tone
Spinal anestgesia considered over general anesthesia in neonates or infants at risk for
Postop apnea
Doubling the distance from a radiation source
Decreases exposure to one quarter of the original
Sodium nitroprusside
Elevated mixed venous, SNP tachyphylaxis, and metabolic acidosis
Imperforate anus often has
Neural tube defects
Aortic cross clamp leads to
Increase in coronary blood flow
Inhalation induction faster in
Pregnant patient due to increased minute ventilation, decreased FRC, decreased MAC requirement
Hypocalcemia
Prolonged qt
Aortic regurgitation
Nitroprusside
TPN after one month will lead to
Increased PT time and will require vitamin K supplementation
Don’t give inotropes to someone with hocm bc it will increase HR thus
Decrease in strike volume and myocardial perfusion
Tourniquet leads to anaerobic metabolism and localized acidosis
When released leads to metabolic acidosis
Cardiac surgery goes more with
AION
Maintain CPAP during
Inhalational ventilation is useful in a child with acute epiglottis
Oligohydramimos does not lead to
Uterine rupture
One side effect of terbutaline is
Hypokalemia and hyperglycemia
Radiation exposure is inversely proportional to the
Square of the distance
PGE1 common side effect is
Apnea
Elderly patients have an increased sensitivity to the
Synthetic opioids fentanyl, sufentanil and alfentanil
Symptomatic severe hyponatremia one thing not to give is
Normal saline
Can give hypertonic and intubate if needed
Troponin is more sensitive than CKMB for detecting
Myocardial injury
Type 1 CPRS is due to a
Minor injury
Prevent dilutional coagulopathy by giving
FFP
Vasopressin increases
Cerebral perfusion pressure and cerebral oxygenation
Dosing of single shot caudal epidural
1 mg/kg
TEG
MA-> platelets
K value prolonged-> cryoprecipitate
R value prolonged-> FFP
Teardrop configuration-> antifibrinolytics
Monopolist cautery is associated with increased potential for AICD
Discharge
In infants and children under 5 yo first sign of high or total spinal is
Apnea
As temperatures decrease gases become more
Soluble
Ulnar nerve is
Medial and up in axillary nerve block
Neural tube defects go with
Folate deficiency
Iv loading is least effective for preventing
Contrast induced nepropathy
C Botulinum gram positive anaerobic treat with
Equine serum antitoxin
Seizures can form from
Hyperglycemia
Child Pugh score for liver disease does not take into account
Creatinine
Morbidly obese patients
Increase in butyrylcholinesterase and extracellular fluid volume
Use ideal body weight for
Rocuronium/vecuronium
Total body weight
Maintenance infusion dose of propofol/ succinylcholine
Ovarian arteries supply up to 15% of
Uterine blood flow
Pituitary is located in
Sella turcica
Keep pt on steroids and give stress dose if pan hypopituitarism
Hypersecretion of pituitary
ACTH results in Cushing syndrome
Excess prolactin leads to galactorrhea
Gigantism excess GH
Also get headache, papilledema, and visual disturbances with compression of optic nerve
Oxytocin
Contraction of uterus
Promotes milk secretion
Vasopressin works at
Collecting tubules
Constriction of vascular smooth muscle
Diabetes insipidus
Central due to less vasopressin made by hypothalamus
Nephrogenic the hypothalamus is making it but renal tubules not using it
Very concentrated urine
Hypernatremia
Diabetes insipidus
Urine osmol <300 and 24 hour urine volume>50 ml/kg
Give DDAVP and isotonic crystalloid for
Nephrogenuc diabetes insipidus
Small cell lung carcinoma leads to
SIADH
SIADH do
Fluid restriction
SIADH
Fluid restriction can consider hypertonic saline and lasix
Hyperglycemia is seen in
80% post cardiac surgery
Glucose>126 more then 2 occasions is
Diabetes
Type 1 diabetes
T cell mediated destruction of pancreatic beta cells
Insulin
Stimulation of cellular uptake of glucose specifically in skeletal muscle, adipose, cardiac cells
Not dependent on glucose
Brain liver immune cells
Suppression of gluconeogenesis and lipolysis
Leads to glycogen formation
Glyburude glipizide leads to
Insulin secretion
Met form in
Suppresses excessive hepatic glucose release
Stop metformin 24 hours
Before surgery
End organ complications DM
Atherosclerosis, increased incidence post op mi
Nepropathy
Neuropathies
DM can lead to
Atlantoaxial instability making difficult laryngoscopy
Hold oral hypoglycemics
24-48 hours preop
Hypo is worse than
Hyperglycemia
Sugar above 200 leads to dehydration poor wound healing
10-15 ropi for
Spinal
Should have inability for sustained leg left
Epidural hematoma
Progressive loss of sensation or weakness in lower extremities bilaterally
Loss of bowel or bladder function
Severe acute onset severe back pain
More likely if female or hx of GI bleed
Epidural hematoma treatment
If weak stop the epidural
Check how much you gave through epidural
Support MAP if hypotension
Get MRI and neurosurgery involved
Need to be fast
Get laboratory tests
If needed
Don’t pit catheter in
Crazy ppl
Infection risk higher at day
7 and after so should take out
Pencil point is better than
Cutting needle
Get
ASRA app
Propofol infusion
50 mcg/kg/min both respiratory depressant and bronchodilaton
Decrease tidal volume increase RR
Attenuates Vagal induced bronchoconstriction
Propofol does not enhance
NMB
Peak effect at 100 seconds
Main loss after bolus dose is due to redistribution
Administration of what is most effective for vasogenic cerebral edema
Steroids
Help lower ICP
Also use corticosteroids in treatment of pseudo tumor cerebri
Loop diuretics like furosemide can
Help lower icp
Decrease in ICP with mannitol is seen at about
30 minutes
Inhaled volatile anesthetics will have increased pharmacodynamic effect in children with
Cerebral palsy
MAC requirement is much lower
Even lower if on antiepileptic
Thus you need less gas
Increase in creatinine clearance occurs with pregnancy returns to prepregnant levels
8 to 12 weeks postpartum
The duration of action of epidural bupi and ropi is not changed much by adding
Epi
Not true of peripheral blocks
Carbohydrate load can precipitate attack of
Hypokalemic periodic paralysis
Carbohydrates broken into sugars which stimulate the pancreas to secrete insulin
Psuedocholinesterase breaks down
Ester local anesthetics
Mivacurium
Succ
Safest induction for this patient is
Iv prop and rocc with psuedohypertrophic cardiomyopathy
Can’t give cpap to nonventilated lung if being
Lavaged
Volatile anesthetics prolong the
QT in a dose dependent manner
Less aldosterone leads to less
Water resorption
Progesterone mediated smooth muscle relaxation decreases LES tone and impairs
Esophageal peristalsis and intestinal motility during pregnancy
Placenta percreta leads to higher risk of
Hemorrhage bc it is more invasive
A point of care glucose test strip is best way to see if fluid is
CSF or normal saline
Glucose is present in CSF
40-70 but not in normal saline
Intrathecal catheter give ten times less dose
Gradual decreases in fetal heart rate at or after the peak of uterine contractions
Are termed late decelerations
Large volumes of chloroprocaine can cause
Muscle spasms
Prone patients wiry ARDS helps with
Ventilation perfusion matching
Sodium citrate increases gastric pH which is good in case patient
Aspirates
Lidocaine decreases seizure duration so don’t use for
ECT
High leak pressure replace with
Smaller tube
Aortic arterial waveform has a less pronounced
Diastolic wave
Postherpetic neuralgia
Age is big factor
RSBI elevation is bad
Excess C02 what can help is using lower respiratory quotient like more lipid content in the TPN
Lipids have lowest respiratory quotient at 0.7
Carbohydrates have highest at 1.0
Neostigmine slows
HR and bronchoconstriction
Tourniquet to 250 mmHg for
Bier block
Provides muscle relaxation also
Usually .5% lidocaine and don’t need epi
Easy rapid onset
Can give 25 to 50 ml of lidocaine
No bupi bc can cause LAST
Local anesthetic goes through veins and gets nerves around it with
Bier block
Tourniquet with Bier block can come off after
25 minutes
After 25 min get protein binding of LA and don’t release too soon can lead to LAST
Local anesthetics have
Inherent vasodilation affects except cocaine
Epi 1:200000
5 mcg/ml
R isomers of LA are more
Toxic
LAST due to too much local anesthetic
Systemically
Get CNS symptoms and hypotensivs
Give benzo
20% lipid solution for LAST and use 100 ml bolus and infusion at 2.5 ml/kg
Lower dose epi(1 ug/kg)
Succ goes through plasma and psuedocholinesterase can break succ down in
Plasma before it gets to neuromuscular junction
Succ binds
Alpha units of nicotinic cholinergic receptors
Psuedocholinesterase made in
Liver
Dibucaine local anesthetic that usually inhibits psuedocholinesterase
Normal is 80%
If dibucaine of 20 it will prolong Succ duration a long time. Need to start sedation and give psuedocholinesterase through FFP
Acetylcholinesterase inhibuted by
Neostigmine to increase Ach to stop neuromuscular blockade
Physostigmine passes
BBB
Organophosphate poisoning treatments
Atropine
Extra junctional nMJ stay open
Longer so get hyperkalemia
Somatic nervous system bonds at
Nicotinic receptor
Physostigmine does cross
BBB but neostigmine does not
Pancuronium prolonged in patients with
ESRD
Suggmadex not approved for patients with
ESRD
Calcium leads to lots of AcH release and thus
Resistance to neuromuscular blocking agents
Inhaled agents potentiate both depolarizing and nondepolaring. Same with magnesium
Opioid tolerance if need to keep giving
Bigger dose
Opioid mu receptor itching treat with
Naloxone
Neuraxial not histamine mediated
Neuraxial opioids act at
Substantial gelatinosa and periaqueductal gray
Mu2 has bad side effects
100 mcg iv =
33 mcg epidural
Emergence delirium decreased with
Midazolam when giving ketamine
Propofol potentiates
Hypoxic pulmonary vasoconstriction
Precedex
Inhibit NE release, decrease MAC, preserve respiratory drive
Decrease SVR and HR
Bolus leads to reflex HTN so give slow
Moca need
250 CME credits need to be achieved over a 10 year cycle
Intracranial rumors cause central diabetes insipidus
Treat with desmopressin
Increased risk of epidural hematoma in patients with
Ankylosis spondylysis
Upper extremity tourniquet should be inflated to at least 50 mm Hg above
SBP
Need at least 100 above systolic for lower extremity surgeries
Tramadol and TCAs lower
Seizure threshold
Tramadol is a
Partial opioid agonist
Tension pneumocephalus can occur when nitrous oxides is used after a
Recent craniotomy
Delayed awakening can be seen and the diagnostic study of choice is a CT scan
Aminoester reaction think
PABA
Aminoamide reaction think methylperaben
Amniotic fluid embolism leads to
Intense pulmonary vasospasm
Typical AVM consists of
Feeding arteries, a nidus, and draining veins
Neuromonitoring during resection of AVM is important need to look at
Sensory and motor
Parasympathetic nervous system predominates in
Newborns so atropine is best for bradycardia
Myotonic dystrophy
Gastric atony
Sucralfate does not change pH of
Gastric fluid
Helps with ventilator associated pneumonia
A lumbar sympathetic block is very close to the
Psoas major
PPV increases intrathoracic pressure which in turn increases
IVC pressure
IABP is placed via the
Femoral artery
Contraindications to IABP
Moderate to severe aortic disease
Severe peripheral vascular disease
Tigecycline helps against
MRSA and gram negatives
Inhaled volatile anesthetics will have increased
Pharmacodynamic effect in children with CP
Pneumo will double in 10 minutes if giving
Nitrous oxide
Tension pneumocephalus after dural closure
SF6
Avoid nitrous oxide for 4 weeks
Cuff of ETT keep less then
30
Nitrous can increase this
Just using volatile anesthetics causes
Arterial hypocarbia and alveolar ventilation
Apenic threshold is high
Volatile anesthetics inhibit
HPV
Des
1 Mac = 6% or 6% at sea level 6% of 760 is 46 mm Hg
Isoflurane is a variable bypass
Vaporizer
1.2% x 760 mm Hg = 9
No % change needed at altitude
ISO into Sevoflurane vaporizer
Sevo has lower vapor pressure
Then will get higher percentwge bc iso has higher vapor pressure
Central compartment falls by 50% in infusion
Context sensitive half life
Remifentanyl small
Context sensitive half life
Phase 1 cyt 450
Oxidation reduction hydrolysis of lipophilic drugs
Potency
Relative dose of two drugs
First drug on graph more potent
Efficacy intrinsic ability of a drug to produce clinical affect-which drug goes higher on the curve
Anesthetics decrease
Amplitude and increase latency of SSEPs
Ketamine and etomidate
Increase amplitude of signals
NMBs are good for SSEPs
They eliminate background noise but can’t use when looking at MEPs
SSEPs monitor
Posterior columns so can have anterior column injury without knowing it
Warfarin inhibits synthesis of
Vit K dependent clotting factors
LMWH
Selective inhibition of factor 10a
Monitor with anti factor 10a
Can’t monitor with PT/PTT
Heparin acts on
AT3 and look at PTT
Xarelto Apixiban
Factor 10a inhibitor
Citrate binds
Calcium and is the anticoagulant in stored blood products
Citrate metabolized to
C02 and then bicarbonate
Citrate toxicity treatment give
IV calcium
Thiazides work at
Distal convoluted tubule
Acetazolamide blocks catholic anhydrase which is needed to block
Bicarbonate so you pee bicarbonate out and get acidosis
Acts at proximal convoluted tubule
Furosemide acts at
Thick ascending limb
Magnesium prolongs
NMDB and depolarizing blockers
Antagonism of NMDA receptors
Magnesium side effect rapid
Flushing and hypotension
1.5-2 is normal
Mag in plasma
Cardiac arrest at 20
ECG changes at 5-10
Loss of deep tendon reflexes at 10
Inhaled nitric oxide
Selective dilation of pulmonary vasculature
CGMP mediated
Prostaglandins dilate
Afferent arteriole
COX leads to constriction of afferent arteriole
Dig increases intracellular
Calcium
Low K and Mg
Get short qt interval and st segment depression
Organophosphate poisoning treatment
Atropine
Competitive muscarinic blocker
Prophylaxis for nerve gas
Pyridostigmine
But atropine is the acute treatment which blocks Ach effect
Tramadol
Mu receptor agonist
Increases serotonin
Reuptake of norepinephrine
Avoid with MAOis
Tramadol is a prodrug and needs CYP2D6 to be activated
TEE most sensitive for detecting
Myocardial ischemia
PCWP is least specific
Give precurization dose
10% of ED95 dose it is 0.03 mg/kg
Phenylephrine causes increased
Afterload and not good for patients with MR
IO line
Proximal humerus
Proximal tibia
Distal Tibia
Sternum
Biggest risk factor for meconium passage is
Later gestational age
Maternal steroids should be given when birth is anticipated between
24 and 34 weeks gestation, when fetal lungs are immature
Prazosin
Selective alpha 1 receptor antagonist
Max Epi dose tumescent lidocaine is
0.055 mg/kg
Don’t give what medication to children following tonsillectomy
Codeine
Barbiturate infusion
Decreases CMR02 and thus increases jugular mixed venous
Oliguria
Sympathetic activation leads to
Decrease urine output
Newborn lung is less compliant than
Adult
Gilbert’s disease most increases risk of
Jaundice after multiple transfusions of pRBCs
Gilbert’s defective enzyme is
Bilirubin glucuronyl transfersase
Cyclosporine can cause
Nephrotoxicity not pulmonary toxicity
Difficulty swallowing due to esophageal atresia in patients with
TEF
Succ hyperkalemic arrest in patients with muscular dystrophies is due to
Rhabdomyolysis
Only do LP
After imaging completed for HA
Greater thermistor temperature change in
Low cardiac output states
Less temperature change if high cardiac output bc less time to mix of injectate to blood
TR will lower
Cardiac output measure by thermodilution
Takes longer for injectate to reach pulmonary artery where it is measured so will show up as lower CO
T12-L1 and S2-S4 is
Secondary stage of labor
Fat embolism don’t give
Heparin
Nitrous oxide does not cause
Uterine relaxation
Pidendal block for
Stage 2
Can also do remi infusion or inhalational induction with nitrous
Hepatopulmonary syndrome improves with
Sitting
A-a gradient increased
Heart rate generation is dependent on the
Donor atrium
Transplanted heart has
Less variability and higher intrinsic HR(eating between 90 to 110
Toxic methemoglobinemia
IV methylene blue
Ketamine less desirable for patient with
Coronary artery disease it may potentiate the sympathetic surge seen with ECT resulting in increased myocardial o2 demand and potential ischemia
Acute herpes zoster most common dermatome distribution is
Thoracic
Alkalization of urine using
Carbonic anhydrase inhibitor
Don’t use benzos for
Acute mountain sickness
LV is perfused during
Diastole
Methadone is hard to
Titrate
B2 agonists like ritodrine
Relax uterine contractions and increase uterine blood flow
To help with thoracic aortic aneurysm stent place heart in
Transient cardiac asystole
Superior laryngeal nerve
Voice gets tired when talking more
LV is primarily perfused during diastole so
Longer systolic time is bad bc it leads to less diastolic time
TPN is most associated with
Thrombophlebitis and infection
Safe anesthesia agents in MH include
Nitrous oxide
Can’t use succ or volatile anesthetics
Sodium bicarbonate needed for normal pH formula is
0.2 x patient weight in kg x base deficit
Myotonic dystrophy you don’t need
PFTs
Persistive vegetative state patients can
Open eyes
Norepinephrine should not be administered IM
Can cause local ischemia and tissue necrosis
Ketamine
Sch 3 drug
Sch 1 drugs
Very high abuse potential such as cannibis
Most common defect associated with TEF is
Congenital heart defects
Glycopyrolate is poorly transferred across
Placenta
Hypoplastic left heart associated with
ASDs
2% lidocaine can undergo
Ion trapping and potentially accumulate in the fetus causing fetal acidosis
Less functional Ach receptors with
Myasthenia gravis
Need to give more Succ
Static compliance measures the lung at a
Fixed volume
Renin release is increased in
Cirrhotic patients
Treatment of methemoglobinemia in G6pd deficiency is
Ascorbic acid not methylene blue
Oligohydramimos is not associated with
Placental abruption
Impaired platelet aggregation makes hemostasis hard in
Dialysis patients
Phenylephrine increases
Afterload thus decreasing cardiac output leading to lower mixed venous
Heparin resistance if
AT3 levels low platelet count above 300000, preop heparin, use of low molecular weight heparin, age>65
SIADH patients are
Euvolemic or hypervklemic
Beat to beat variability is normal
Fetal heart rate intermittently varies 10 beats per minute from baseline
Late decel
Occurs after onset of uterine contraction
TURP main complication is
Hypothermia
Alveolar hypoxia is induced due to
Decreased atmospheric pressure resulting in diffuse hypoxic pulmonary vasoconstriction
Walking uphill or squatting helps with
Spinal stenosis
Compartment syndrome occurs when tissue perfusion exceeds
Local perfusion pressure
Idiopathic intracranial HTN
Can put in catheter intrathecal and drain CSF
CSF volume is higher on a ml/kg basis in children than in
Adults
Cyanide toxicity due to fire first line treatment is
Hydroxycobalamin
LV did tension coming off bypass and lateral wall hypokinesis due to
Embolus in left coronary artery
For a turp need to also block
Obturator
Most appropriate therapy to reduce rate of vasospasm following clipping of a ruptured berry aneurysm is
Nimodipine
Terbutaline can cause
Hyperglycemia
Anterior mediastinal mass cause compression of the
Tracheobromchial tree
If minute ventilation exceeds fresh gas flow
H in j k UK mi my my
Hu mlol
I’m
K kit Lu
If patient is anticoagulated can’t do
Neuraxial anesthesia
Always start hydration first before giving insulin in a patient with
DKA
Decreasing pKa and higher pH means more ionized so works faster
Chloroprocaine is rapid due to high concentration
Allalization speeds onset of local
Anesthetic. An abscess is acidic so putting local in it won’t work well
Epi 1:200000
5 ucg/ml
Epi prolongs shorter acting LAs like
Lidocaine
Ester
Paba
IV>tracheal>intercostal>caudal>paracervical to
Epidural
Suppress local anesthetic seizure with
Benzos
Toxicity of local anesthetic potentiate by
Acidosis hypercarbia pregnancy
Cocaine to city treat with
Nitroglycerin(don’t give beta blockers first)
LA toxicity
Hyperventilate
Lipid emulsion
Low dose Epi
No vasopressin
Methemoglobinemia
Oxidized iron from Fe2+ to Fe3+ doesn’t bind Hgb
EMLA cream is
Lidocaine and prilocaine
Can cause methemoglobinemia
Peak lidocaine levels occur
12-14 hours after injection in tumescent lidocaine injection
Local anesthetics are weak bases attached to
Alpha 1 acid glycoprotein
2 alpha subunits is where
NMBs bind
Acetylcholinesterase is located in
Post junctional receptor
Succ increases
LES tone
Succ phase 2 similar to
NMDB block
Succ can give in
Cerebral palsy and renal failure
Succ induced hyperkalemia in
Burns and patients with muscular dystrophy can release potassium with rhabdomyolysis
Panc prolonged most with
Renal failure
Succ binds
Post junctional receptors
Hypokalemic periodic paralysis avoid
Hypothermia, stress, carbohydrate loads(more insulin release) beta agonists
Avoid Succ in
Hyperkalemic periodic paralysis
Pancuronium can increase
HR
Succ can cause
Bradycardia in neonates and infants
Neostigmine inhibits
Psuedocholinesterase as well so Succ May be needed
Blocks exocytosis of pre synaptic Ach
Botulism and tetanus
Atropine for too much
Neostigmine leading to SLUDGE
TIVA and nitrous don’t prolong
Neuromuscular blockade do have to give more
Mg increases
ND and depolarizing NMBs
And calcium channel blockers
Lithium clindamycin aminoglycosides
Adductor Pollicis is last to recover from
Nmdb so if this is good we are good
Orbicularis oculi
Block is more rapid and recovery occurs sooner
TOF>.9 is
Best
Double burst easier to detect fade bc only
Two lines
Residual neuromuscular blockade fade is due to
Residual paralysis
Desflurane potentiate
NMDB the most
Femoral
Ventral Rami L2-4
If sartorius stimulated during femoral nerve block redirect
Needle deeper and lateral
NAV
Order of structures
Saphenous from ventral Rani
L3-L4
Sensory only
Sciatic nerve block
Ventral Rami L4-5 and S1-S3
For sciatic block want to see
Plantar flexion of ankle/foot
2% lidocaine
20mg/ml
Uterine rupture
Fetal bradycardia
Diffuse pain even with epidural
1/10 for
Intrathecal dose
1cc .2% ropi
Skin test gold standard to diagnose
Anaphylaxis
DLCO is increased in
Obesity
What volatile anesthetic fucks up SSEPs the most
Isoflurane
3 to 1
Iv to oral morphine
Continue pyridostigmine
On day of surgery
For mediastinal mass
Two pulse ox
Right inonimste artery compression check with right radial artery
Lose etc02 during mediastinal mass
First hand ventilate, if can’t then made compression, try to pass rigid brinchoscope past obstruction then move in lateral or prone, if not open chest and CP bypass
Right arterial line tracing diminished during mediastinoscopy
Compression of Inonimate artery causing artificially low bp readings
Complication of mediatinoscopy is
Recurrent laryngeal nerve injury
Leads to hoarseness
Myasthenia gravis symptoms are usually
Global
AOrtic dissection could have massive
Blood loss
Tachycardia is a side effect of
Nitroglycerin
For aortic dissection if BP 75/45 in lower extremity
Attempt to increase perfusion pressure distal to cross clamp by placing shunt
If bp drops after cross clamp and ST changes
Tell surgeon to immediately reapply clamp. Once BP improves slowly remove clamp while adding infusion of norepinephrine to increase SVR