Trivia

Question 1

How sensitive is PARR for the detection of lymphoma in cats?

Answer 1

80% sensitive

Withrow and McEwan text

Question 2

Brand name for Mechlorethamine

Answer 2

Mustargen

Question 3

Brand name for Cyclophosphamide

Answer 3

Cytoxan

Question 4

Brand name for Lomustine

Answer 4

Gleostine

Question 5

Chemical abbreviation for Lomustine

Answer 5

CCNU

Question 6

Brand name for Doxorubicin

Answer 6

Adriamycin

Question 7

Generic name for Palladia

Answer 7

Toceranib

Question 8

Generic name for Tanovea

Answer 8

Rabacfosadine

Question 9

Generic name for Laverdia

Answer 9

Verdinexor

Question 10

Mutations in what exons of the cKit gene can be a strong negative prognostic indicator in canine MCTs?

Answer 10

exons 8 and 11

Question 11

What are 2 proliferation markers used to prognosticate MCTs?

Answer 11

Ki67 and AgNORs

Question 12

What do you call the systemic form of mast cell disease?

Answer 12

Mastocytosis

Withrow

Question 13

What is the most common cutaneous tumor in the dog?

Answer 13

Mast cell tumor

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Question 14

What is the most common cutaneous tumor in the cat?

Answer 14

basal cell tumor

Question 15

What is the second most common cutaneous tumor in the cat?

Answer 15

Mast cell tumor

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Question 16

What is released when a mast cell degranulates?

Answer 16

Heparin, histamine, proteases, cytokines, and chemokines

Question 17

What is unique about mast cell tumors in young dogs?

Answer 17

They may spontaneously regress

Question 18

Do dogs with primary GI mast cell tumors do well?

Answer 18

Nyoooo. In one study, only 40% of dogs were still alive at 30 days and only 10% were alive at 6 months after their first hospital admission.

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Question 19

What is Darier’s sign?

Answer 19

The eliciting of erythema and an urticarial wheal by stroking or rubbing a (MCT) lesion

Question 20

Why do we put MCT dogs on famotidine?

Answer 20

They can develop GI ulcers due to histamine released from MCT granules acting on parietal cells via H2 receptors, resulting in increased hydrochloric acid secretion.

Question 21

for Mast Cell tumors: What is the mitotic count (per 10hpf) break point important for prognosis ?

Answer 21

4
Decreased survival times have been reported with mitotic counts >4.

Withrow

Question 22

For Mast Cell Tumors: What tumor locations are associated with a worse prognosis?

Answer 22

preputial, scrotal, subungual, and at mucocutaneous sites

Withrow

Question 23

Is lymph node metastasis a major prognostic factor with mast cell tumors?

Answer 23

Not really. Dogs can have long MSTs even with metastasis to the draining lymph node.

Withrow

Question 24

Does visceral/disseminated MCT carry a good or bad prognosis?

Answer 24

Very bad. Aggressive treatment is necessary

Question 25

What is the benefit of taking chest radiographs during staging for a dog with mast cell tumor(s)?

Answer 25

Thoracic radiographs rarely demonstrate metastasis; however, it is reasonable to procure them before an expensive or invasive procedure to rule out occult cardiopulmonary disease that could complicate anesthesia or unrelated disease processes (primary lung tumor, etc.)

Question 26

Define myelophthisis

Answer 26

a type of bone marrow failure that occurs when abnormal tissue replaces hematopoietic bone marrow tissue