Trivia

Question 1

How sensitive is PARR for the detection of lymphoma in cats?

Answer 1

80% sensitive

Withrow and McEwan text

Question 2

Brand name for Mechlorethamine

Answer 2

Mustargen

Question 3

Brand name for Cyclophosphamide

Answer 3

Cytoxan

Question 4

Brand name for Lomustine

Answer 4

Gleostine

Question 5

Chemical abbreviation for Lomustine

Answer 5

CCNU

Question 6

Brand name for Doxorubicin

Answer 6

Adriamycin

Question 7

Generic name for Palladia

Answer 7

Toceranib

Question 8

Generic name for Tanovea

Answer 8

Rabacfosadine

Question 9

Generic name for Laverdia

Answer 9

Verdinexor

Question 10

Mutations in what exons of the cKit gene can be a strong negative prognostic indicator in canine MCTs?

Answer 10

exons 8 and 11

Question 11

What are 2 proliferation markers used to prognosticate MCTs?

Answer 11

Ki67 and AgNORs

Question 12

What do you call the systemic form of mast cell disease?

Answer 12

Mastocytosis

Withrow

Question 13

What is the most common cutaneous tumor in the dog?

Answer 13

Mast cell tumor

Withrow

Question 14

What is the most common cutaneous tumor in the cat?

Answer 14

basal cell tumor

Question 15

What is the second most common cutaneous tumor in the cat?

Answer 15

Mast cell tumor

Withrow

Question 16

What is released when a mast cell degranulates?

Answer 16

Heparin, histamine, proteases, cytokines, and chemokines

Question 17

What is unique about mast cell tumors in young dogs?

Answer 17

They may spontaneously regress

Question 18

Do dogs with primary GI mast cell tumors do well?

Answer 18

Nyoooo. In one study, only 40% of dogs were still alive at 30 days and only 10% were alive at 6 months after their first hospital admission.

Withrow

Question 19

What is Darier’s sign?

Answer 19

The eliciting of erythema and an urticarial wheal by stroking or rubbing a (MCT) lesion

Question 20

Why do we put MCT dogs on famotidine?

Answer 20

They can develop GI ulcers due to histamine released from MCT granules acting on parietal cells via H2 receptors, resulting in increased hydrochloric acid secretion.

Question 21

for Mast Cell tumors: What is the mitotic count (per 10hpf) break point important for prognosis ?

Answer 21

4
Decreased survival times have been reported with mitotic counts >4.

Withrow

Question 22

For Mast Cell Tumors: What tumor locations are associated with a worse prognosis?

Answer 22

preputial, scrotal, subungual, and at mucocutaneous sites

Withrow

Question 23

Is lymph node metastasis a major prognostic factor with mast cell tumors?

Answer 23

Not really. Dogs can have long MSTs even with metastasis to the draining lymph node.

Withrow

Question 24

Does visceral/disseminated MCT carry a good or bad prognosis?

Answer 24

Very bad. Aggressive treatment is necessary

Question 25

What is the benefit of taking chest radiographs during staging for a dog with mast cell tumor(s)?

Answer 25

Thoracic radiographs rarely demonstrate metastasis; however, it is reasonable to procure them before an expensive or invasive procedure to rule out occult cardiopulmonary disease that could complicate anesthesia or unrelated disease processes (primary lung tumor, etc.)

Question 26

Define myelophthisis

Answer 26

a type of bone marrow failure that occurs when abnormal tissue replaces hematopoietic bone marrow tissue

Question 27

Medications that are poorly tolerated in dogs with the MDR1 mutation

Answer 27

Doxorubricin Mitoxantrone (questionable) Actinomycin D Vincristine Vinblastine

Question 28

Complete response to therapy is X% resolution of tumor

Answer 28

100% ## Footnote According to AAHA / RECIST

Question 29

Partial response to therapy is what % change to tumor size?

Answer 29

>30% reduction in overall tumor size ## Footnote According to AAHA / RECIST

Question 30

Progressive disease is defined as what % change in tumor size?

Answer 30

>20% increase in overall tumor size ## Footnote According to AAHA / RECIST

Question 31

Stable disease is quantifiably defined as what?

Answer 31

<30% reduction or <20% increase in tumor size ## Footnote According to AAHA / RECIST

Question 32

What virus has been correlated with SCC development in dogs and cats?

Answer 32

Papillomavirus

Question 33

What is another name for squamous cell carcinoma in situ unrelated to UV exposure?

Answer 33

Bowen's carcinoma or Bowenoid in situ carcinoma (BISC)

Question 34

What is another name for squamous cell carcinoma in situ possibly caused by UV light exposure in light-haired cats?

Answer 34

Actinic keratosis

Question 35

Between actinic keratosis and Bowenoid in situ carcinoma, which disease process is usually a single lesion and which is usually multicfocal?

Answer 35

actinic keratosis is usually a solitary lesion accompanied by solar elastosis and fibrosis of the skin, while Bowenoid in situ carcinoma can occur anywhere on the body, in areas with and without sun exposure, and usually appears as multifocal lesions

Question 36

Most common location for cutaneous SCC in cats?

Answer 36

Top of the head

Question 37

Metastatic rate for cutaneous squamous cell carcinoma in dogs

Answer 37

3-9% (rare)

Question 38

What is most common malignant digit tumor in dogs and cats?

Answer 38

SCC