Triptans

Question 1

Almotriptan

Answer 1

Repeat in 2 hours
For children > 12 years old
Reduce in hepatic and renal
Major 3A4 substrate

Question 2

Eletriptan

Answer 2

Repeat in 2 hours
Avoid in hepatic
Major 3A4 substrate (avoid inhibitors)

Question 3

Frovatriptan

Answer 3

Repeat in 2 hours
Long half-life (26 hours)

Question 4

Lasmiditan

Answer 4

5HT-1F
Controlled substance (C-V)
One dose in 24 hours
Avoid in hepatic
Don’t drive after 8 hours of taking

Question 5

Naratriptan

Answer 5

Repeat in 4 hours
CI in hepatic and renal

Question 6

Rizatriptan

Answer 6

Tablet/ODT
Children > 6
DDI w/propranolol (decrease rizatriptan dose)
Repeat in 2 hours

Question 7

Sumatriptan

Answer 7

SC, Nasal spray, Tablet
Repeat SC in 1 hour; the rest, repeat in 2 hours
CI: hepatic

Question 8

Sumatriptan/Naproxen

Answer 8

Repeat in 2 hours
Children > 12 years old
Avoid in renal and hepatic

Question 9

Zomitriptan

Answer 9

Tab/ODT, Nasal spray
Repeat in 2 hours
Avoid in mod-to-severe hepatic
Nasal spray approved for children > 12 years old