Brainscape's Knowledge GenomeTM


Top Flashcards (Certified)
All Flashcards

Neurology > Antiepileptic > Flashcards

Antiepileptic Flashcards

1
Q

Brivaracetam

A

Synaptic vesicle protein 2A
Angioedema, Neutropenia
Lower in hepatic
C-V controlled substance

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Cannabidiol

A

MOA: Unknown
Anemia, Hepatotoxicity, Infections
Used in Lannox-Gastaut or Dravet
Highly protein bound
Mod 2C19 inhibitor
Lower in hepatic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Carbamazepine (MOA & ADRs)

A

Na channel
Agranulocytosis
Aplastic anemia, Leukopenia
DRESS, SJS/TEN
HYPOnatremia
Hyperhomocysteinemia
Osteoporosis
Weight GAIN
Squamous cell carcinoma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Carbamazepine (Clinical Pearls)

A

HLA-B1502 & HLA-A3101 testing prior to initiation (esp in Asians)
Inducer of 2B6 & 3A4
Auto-induces it’s own metabolism (increase dose over 3-4 weeks)
Therapeutic range: 4-12 mcg/mL
Highly protein bound
CI: bone marrow suppression

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Cenobamate

A

Na channel and GABA
C-V controlled substance
Shorten QT interval, HYPERkalemia, DRESS, Diplopia
Lower in hepatic/renal, Avoid in hepatic
CI: QT shortening
Inhibits 2C19
Induces 3A4

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Clobazam

A

GABA
SJS/TEN
Titrate slowly with hepatic
Tolerance
Highly protein bound
C-IV controlled substance

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Eslicarbazepine

A

Na channel
Agranulocytosis
DRESS, SJS/TEN
Hepatotoxicity
HYPOnatremia
Hypothyroidism
Lower in renal
Induces 3A4

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Ethosuximide

A

Ca channel
Aplastic anemia, Leukopenia
DRESS, SJS/TEN
Systemic lupus erythematous
Hepatotoxicity, Nephrotoxicity
May also be effective in myoclonic seizures
Therapeutic range: 40-100 mcg/mL

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Felbamate

A

Glutamate
Aplastic anemia, Leukopenia, Thrombocytopenia
SJS/TEN
Hepatotoxicity
Weight LOSS
Lower in renal
CI: pts with hepatic dysfunction or blood dyscrasia(s)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Gabapentin

A

Ca channel
Angioedema
DRESS
Pancreatitis
Weight GAIN
Lower in renal

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Lacosamide

A

Na channel and CRMP-2
DRESS
Arrhythmias, AV block, PR interval prolongation
Lower in renal & hepatic, Avoid in hepatic
C-V controlled substance

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Lamotrigine (MOA & ADRs)

A

Na channel and glutamate
Aseptic meningitis
Blood dyscrasias
DRESS, SJS/TEN
Hemophagocytic lymphohistiocytosis
Squamous cell carcinoma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Lamotrigine (Clinical Pearls)

A

Initial dosing:
a) LOWER if on valproic acid
b) HIGHER if on carbamazepine, phenytoin, phenobarbital or primidone
Lower in hepatic
Oral contraceptives may reduce concentrations

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Levetiracetam

A

Synaptic vesicle protein 2A
Blood dyscrasias
SJS/TEN
Lower in renal

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Oxcarbazepine (MOA & ADRs)

A

Na & Ca channels
Blood dyscrasias
DRESS, SJS/TEN
Hepatotoxicity
HYPOnatremia
Hypothyroidism
Osteoporosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Oxcarbazepine (Clinical Pearls)

A

Lower in renal
HLA-B1502 & HLA-A3101 testing
Active form: 10-monohydroxy metabolite

17
Q

Perampanel

A

Glutamate
DRESS
Behavioral problems
Suicidal/homicidal ideation
Lower in hepatic, Avoid in hepatic
Highly protein bound
C-III controlled substance

18
Q

Phenobarbital (MOA & ADRs)

A

GABA and Na channel
Aplastic anemia, Leukopenia
SJS/TEN
Hyperhomocysteinemia
Osteoporosis

19
Q

Phenobarbital (Clinical Pearls)

A

Primidone is metabolized to phenobarbital
IV preparation contains propylene glycol
Lower in renal & hepatic
CI: severe hepatic, porphyria, and airway obstruction
Induces 3A4 (strong)
Therapeutic range: 10-40 mcg/mL
C-IV controlled substance

20
Q

Phenytoin (MOA & ADRs)

A

Na channel
Blood dyscrasias
DRESS, SJS/TEN
Hepatotoxicity
Hyperhomocysteinemia
Lymphadenopathy
Osteoporosis
Gingival hyperplasia

21
Q

Phenytoin (Clinical Pearls)

A

IV preparation contains propylene glycol
Phenytoin is a vesicant (SC/IM not recommended)
Lower in hepatic
HLA-B*1502 & 2C9 - associated with SJS/TEN
Inducer of 3A4 (strong)
Zero-order PK
Therapeutic range: 10-20 mcg/mL (total) or 1-2 mcg/mL (free)
Highly protein bound

22
Q

Pregabalin

A

Ca channel
Angioedema
Peripheral edema
Rhabdomyolysis
PR interval prolongation
Thrombocytopenia
Visual field defects
Lower in renal
C-V controlled substance

23
Q

Rufinamide

A

Na channel
DRESS, SJS/TEN
Leukopenia
QT shortening
Avoid in hepatic
CI: Shorten QT interval

24
Q

Tiagabine

A

GABA
SJS/TEN, suicidal ideation, infections
Lower in hepatic
Highly protein bound

25
Q

Topiramate

A

Na channel, glutamate, & GABA
Acute glaucoma
Decrease serum bicarbonate levels
Metabolic acidosis
Nephrolithiasis
Oligohidrosis
SJS/TEN
TERATOGENICITY
Lower in hepatic & renal

26
Q

Valproic Acid (MOA & ADRs)

A

Na channel & GABA
DRESS
Hepatotoxicity
Hypothermia
Osteoporosis
Pancreatitis
TERATOGENICITY
Thrombocytopenia
Weight GAIN

27
Q

Valproic Acid (Clinical Pearls)

A

Highly protein bound
Avoid in hepatic
CI: hepatic dysfunction, urea cycle disorders, mitochondrial disease
Therapeutic range: 50-150 mcg/mL

28
Q

Vigabatrin

A

GABA
Weight GAIN
REMS: Visual field deficits or permanent loss
Lower in renal

29
Q

Zonisamide

A

Na & Ca channels
DRESS, SJS/TEN
Metabolic acidosis
Nephrolithiasis
Nephrotoxicity
Oligohidrosis
Lower in hepatic, Avoid in renal
Contains sulfa moiety

Neurology (4 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions