Trigger 7 (TBI) Glial cells

Question 1

name the glial cells in the CNS

Answer 1

CNS: Astrocytes, Microglia, Oligodendrocyte and ependymal cells

Question 2

name the glial cells in the PNS

Answer 2

Satellite cells and schwann cells

Question 3

What are the 3 functional types of microglia and what situations they are associated with

Answer 3

Ramified (starry)-surveillance
Activated:
- Rod: chronic inflammation
- Amoeboid: phagocytic/acute inflammation (becomes hyper-ramified before this)

Question 4

What are the polarisation states of microglia, associated immune molecules and what kind of response?

Answer 4

M0: BDNF and IGF-1
M1: IL-beta, TNF alpha, IFN-gamma. infiltration and neuronal damage
M2: IL-4 and IL-13. Anti-inflammation response (IL-4, IL-10, TGF-beta and IGF-1 released)

Question 5

What are the hallmarks of primed microglia?

Answer 5

increase in MCHII and CD68

Question 6

What happens when primed microglia encounter another immune challenge?

Answer 6

hyperactivated. extremely increased levels of IL-1beta, TNF-alpha, CS14 and iNOS release