Trigger 7 (TBI) experimental models

Question 1

Explain what a controlled cortical impact injury model is and what sorts of brain injuries it is helpful for?

Answer 1

uses a machine that has a set depth to impact the mouse brain at a given location.
useful for concussion, axonal injury and BBB dsyfunction

Question 2

what kind of model is useful to mimic military explosions that lead to TBI?

Answer 2

Blast model: small explosion at end of tube near mouse’s head.

Question 3

What kind of model simulates swelling/intercranial pressure? Explain how it works

Answer 3

Fluid percussion injury model:
inject fluid into the brain.
can be used for blunt force trauma and stroke

Question 4

How do the two Weight drop models differ and what kinds of injuries do the model?

Answer 4

Marmarou’s: diffuse (widespread). metal disk used over skull to prevent fractures. weight dropped onto it
Shohami’s: focal (localised). Weight dropped onto unprotected side of skull