Trigger 2 Flashcards
1
Q
3 main constitutents of circle of willis
A
- anterior cerebal artery
- middle cerebral artery
- posterior cerebral artery
2
Q
Effect of depolarisation on NMDA R
A
- postitive charge repels Mg2+ therefore removed
- allows Ca2+ influx
3
Q
Why is more ROS generated in reperfusion injury?
A
O2 restored so more ROS can be formed
4
Q
Genes transcribed by HIF
A
- EPO
- VEGF
- angiogenesis genes
- eNOS
- iNOS
5
Q
Steps in atherosclerosis formation
A
- endothelial dysfunction
- stable plaque formation
- t cell activation
- plaque rupture and clotting
6
Q
What are the 2 gold standard cardiac markers for MI tests?
A
high sensitivity cardiac specific troponin I/T
- expressed from diff genes to skeletal muscle
7
Q
What activates the extrinsic pathway?
A
Tissue factor release
- acts as R for factor 7
- which binds in presence of phospholipids and Ca2+
- activates factor 10 in presence of phospholipids and Ca2+
8
Q
Give 2 examples of tpa like drugs
A
- clot busters
- altepase and streptokinase
