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GI (2nd year) > Treatments for select GI infections > Flashcards

Treatments for select GI infections Flashcards

1
Q

What do you use for Clostridium Difficile?

A
  • oral vancomycin

- fidaxomicin

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2
Q

What do you use for Campylobacter jejuni?

A
  • Ciprofloxacin

- azithromycin (if allergic to cipro)

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3
Q

What do you use for Salmonella spp.?

A
  • Ciprofloxacin

- azithromycin

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4
Q

What do you use for Shigella spp.?

A
  • Ciprofloxacin

- azithromycin

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5
Q

What do you use for Entamoeba histolytica?

A

metronidazole follow by paromomycin

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6
Q

What do you use for Giardia lamblia?

A

metronidazole

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7
Q

What do you use for Cryptosporidium parvum?

A

nitazoxanide

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8
Q

What do you use for Cyclospora cayetanensis?

A
  • TMP-SMX

- ciprofloxacin (if allergic to sulfa)

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9
Q

What do you use for Shistosoma spp.?

A

praziquantel

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10
Q

What do you use for Echinococcus granulosus?

A

albendazole + praziquantel

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11
Q

What do you use for Necator americanus?

A

Albendazole

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12
Q

What do you use for Strongyloides stercoralis?

A

Ivermectin

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13
Q

What do you use for Trichuris trichuria?

A

Mebendazole

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14
Q

What do you use for Enterobius vermicularis?

A

Mebendazole

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15
Q

What do you use for Ancylostoma spp. (duodenale)?

A

Albendazole

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16
Q

What do you use for Ascaris lumbricoides?

A

Albendazole

17
Q

What do you use for Taenia spp. (saginata/solium)

A

Praziquantel (for adult)

Albendazole (larval - solium)

18
Q

What do you use for Diphyllobothrium latum?

A

Praziquantel

19
Q

What do you use for Trichinella spp.?

A

Albendazole

20
Q

What are the benzimidazoles?

A
  • albendazole
  • mebendazole
  • thiabendazole
21
Q

What is the MOA of benzimidazoles?

A

inhibit microtubule polymerization - reduces glucose transport

inhibit mitochondrial fumarate reductase - causing immobilization and death

22
Q

Ivermectin MOA

A

binds to glutamate-gated Cl-channel

induce hyperpolarization to cause paralysis of worm

23
Q

Nitazoxanide MOA

A

interfere with pyruvate:ferredoxin oxidoreductase enzyme-dependent electron transfer reaction

(no anaerobic energy metabolism)

24
Q

Praziquantel MOA

A

increase cell membrane permeability - leads to loss of intracellular calcium - causing paralysis

25
Q

Pyrantel pamoate MOA

A

stimulates release of ACh and inhibits cholinesterase

  • spastic paralysis of parasite
26
Q

Paromomycin MOA

A

similar to aminoglycosides (30-S subunit)

27
Q

Metronidazole and Tinidazole MOA

A

create nitro-radicals to disrupt DNA

28
Q

Atovaquone-Proguanil MOA

A

atovaquone - interfere with mitochondria electron transport and ATP/pyrimidine synthesis

proguanil - inhibit DHF reductase and thymidylate synthetase of plasmodia to fuck with their DNA synthesis

GI (2nd year) (4 decks)

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