Anti-Ulcer Agents Flashcards
What classes of drugs can be used as anti-ulcer agents?
- H2 receptor antagonists
- Proton pump inhibitors
- Surface acting agents
- PGE1 analogs
- Bismuth compounds
Which drugs are H2 receptor antagonists?
“-tidine”
- Cimetidine
- Famotidine
- Nizatidine
- Ranitidine
Which drugs are Proton Pump inhibitors?
“-prazole”
- Lansoprazole (dexlansoprazole)
- Omeprazole (esomeprazole)
- Pantoprazole
- Rabeprazole
Which drugs are Surface acting agents?
- Sucralfate
Which drugs are PGE1 analogs?
- Misoprostol
Which drugs are Bismuth compounds?
- Bismuth subsalicylate
H2 receptor antagonist MOA
reversibly inhibit H2 receptors on baso-lateral membrane of Parietal cell
Which H2 receptor antagonist has rare adverse effects and what are they?
Cimetidine
- decrease testosterone binding (gynecomatia, galactorrhea)
- blood dyscrasias (neutropenia, thrombocytopenia)
Which H2 receptor antagonist inhibits many CYP450 enzymes?
Cimetidine
Which H2 receptor antagonist is recommended for pregnancy?
Ranitidine
Proton pump inhibitor MOA
inhibit H/K ATPase at parietal cell secretory sites by binding to its sulfhydryl groups
Adverse effects of PPI?
- Clostridium Difficile-Associated Diarrhea
Which PPI is prototypical for CYP450 inhibition?
omeprazole
Which PPIs are used for pregnant women?
- lansoprazole
- pantoprazole
Sulcralfate MOA
cross-link with stomach acid to make polymer that sticks to epithelial cells around ulcer crater
- creates shell around ulcer, prevent acid interaction
- Dosed as QID, take 2 hrs after other meds