Treatments Flashcards
1
Q
What is Ustekinumab?
A
- Anti-IL12p40 monoclonal antibody
- It targets IL-12 and IL-23 and blocks their function.
2
Q
What is Tocilizumab?
A
- Anti-IL6R monoclonal antibody
- Block IL-6 signalling
3
Q
What is Infliximab and adalimumab?
A
Anti-TNF monoclonal antibodies
4
Q
What is Alemtuzumab?
A
- Anti-CD52 monoclonal antibody
- Targets T and B cells
5
Q
What is Rituximab and Ocrelizumab?
A
- Anti-CD20 monoclonal antibody
- Targets B cells.
6
Q
What is Otelixizumab?
A
- Anti-CD3 monoclonal antibody
- Targets T cells
7
Q
What is Daclizumab?
A
- Anti-CD25 monoclonal antibody.
- Targets T cells
- It can been disused due to side effects
8
Q
What is Abatacept?
A
- CTLA-4 Ig Fusion protein
- Targets T cells
9
Q
What is Natalizumab?
A
- Anti-VLA4 monoclonal antibody
- Targets T cell migration
10
Q
What is Finglimod?
A
- Binds to Sphingosine 1-phosphate receptor.
- This means the T cells are retained in the lymph node.
11
Q
What is Nivolumab and Pembolizumab?
A
Anti-PD1 monoclonal antibody
12
Q
What is Atozolizumab?
A
Anti-PD-L1 monoclonal antibodies
13
Q
What is Ipilimumab?
A
Anti-CTLA4 monoclonal antibody
14
Q
What is Omalizumab?
A
- Anti-IgE monoclonal antibody.
- Prevents IgE cross linking and degranulation.
- Used to treat asthma
15
Q
What is Dupilumab?
A
- Anti-IL-4Ra monoclonal antibody.
- Prevents IL-4 and IL-13 signalling.
- Used to treat asthma
16
Q
What is Mepolizumab?
A
- Anti-IL5 monoclonal antibody.
- Used to treat eosinophilic asthma.
17
Q
What is Benralizumab?
A
- Anti-IL5R monoclonal antibody.
- Used to treat eosinophilic asthma.
18
Q
What is Lebrikizumab?
A
- Anti-IL-13 monoclonal antibody.
- No longer used as it is not effective.
19
Q
What is Brodalumab?
A
- Anti-IL-17A monoclonal antibody.
- Blocks IL-17A, IL-17F and IL-25 in asthma
20
Q
What is Tezepelumab?
A
- Anti-TSLP monoclonal antibody
- Blocks TSLP in asthma.
