Treatment Strategy

Question 1

What type of therapy is often initiated at the time of HIV diagnosis?

Answer 1

Highly active antiretroviral therapy (HAART)

Question 2

What are the strongest indications for treatment with these HIV drugs?

Answer 2

Patients presenting with AIDS-defining illness, low CD4+ cell counts (

Question 3

What is the HIV drug ‘regimen’?

Answer 3

3 drugs (to prevent resistance):

1. 2 NRTIs
2. 1 of: NNRTI OR protease inhibitor OR integrase inhibitor

Question 4

What does Raltegravir do to lab values?

Answer 4

Increases creatinine kinase.

Question 5

What TB drug shouldn’t you give with Protease inhibitors? Why not?

Answer 5

Rifampin (a potent CYP/UGT inducer) contraindicated with protease inhibitors because it can decrease protease inhibitor concentration.