Treatment of Heart Failure

Question 1

Phosphodiesterase inhibitors

1) Example
2) Effect

Answer 1

1) Milrinone.

2) Positive Inotrope. Increases CO.

Question 2

B1 adrenoreceptor agonist.

1) Examples
2) Effect

Answer 2

1) Dobutamine and Dopamine.

2) Positive inotrope.

Question 3

Cardiac glycosides.

1) Example
2) MOA
3) Effect

Answer 3

1) Digoxin
2) Inhibits Na+/K+ ATPase=> Increases IC Na+=> Increase Ca2+=> Increase contractility.
Increases vagal nerve activity=> Slows SA node firing and AV node conduction.
3) Positive inotrope.

Question 4

ACE inhibitors

1) MOA
2) Effect
3) Side effects

Answer 4

1) Inhibit ACE=> Decrease Ang II levels=> Decreases Afterload + Decreases Aldosterone release + Decreases sympathetic nervous system activity.
2) Cough, Renal dysfunction, hyperkalemia, Hypotension.