Treatment of Cancer Flashcards
Metastasis definition:
Invasion of cancer into surrounding tissue, and colonization of other locations in the body
Angiogenesis definition:
Growth of new blood vessels from existing vasculature
Why is angiogenesis critical for tumour growth?
Allows new abnormal cells to grow by providing oxygen and nutrients
Tumours secrete ___ to induce blood vessel growth:
GFs
Metastasis occurs when:
Cells detach from parent tumor, enter blood/lymph vessel, exit from circulation, proliferate into the new environment
Carcinoma:
Cancers of epithelial cells lining the surface of organs
Sarcoma:
Cancer of muscle, bone, fat, cartilage, or connective tissue
Leukemia:
Cancer of white blood cells or blood precursor cells
Lymphoma:
Cancers of bone-marrow derived cells that affect the lymphatic system
Blastoma:
Cancer thought to arise from immature or embryonic tissue
80-90% of cancers are what type?
Carcinomas
Why are the majority of cancers carcinomas?
Epithelial cells are the site of extensive cell proliferation and frequent exposure to chemical and/or physical damage
Certain genes that are reported to play a critical role in cancer development:
- DNA proofreading/ repair genes
- Genes that maintain chromosomal integrity
- Oncogenes
- Tumour suppression genes
Tumour progression depends on various factors:
- Mutation rate
- Number of cells in the population
- Rate of cell division
In a healthy cell, rate of damage is equal to ____
Rate of repair
During pathological situations, rate of DNA damage is ____ than the rate of repair:
Greater
How is the risk of developing cancer affected in an individual with inherited cellular DNA mutations?
Increased risk of developing cancer