Treatment of Cancer Flashcards

1
Q

Metastasis definition:

A

Invasion of cancer into surrounding tissue, and colonization of other locations in the body

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2
Q

Angiogenesis definition:

A

Growth of new blood vessels from existing vasculature

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3
Q

Why is angiogenesis critical for tumour growth?

A

Allows new abnormal cells to grow by providing oxygen and nutrients

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4
Q

Tumours secrete ___ to induce blood vessel growth:

A

GFs

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5
Q

Metastasis occurs when:

A

Cells detach from parent tumor, enter blood/lymph vessel, exit from circulation, proliferate into the new environment

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6
Q

Carcinoma:

A

Cancers of epithelial cells lining the surface of organs

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7
Q

Sarcoma:

A

Cancer of muscle, bone, fat, cartilage, or connective tissue

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8
Q

Leukemia:

A

Cancer of white blood cells or blood precursor cells

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9
Q

Lymphoma:

A

Cancers of bone-marrow derived cells that affect the lymphatic system

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10
Q

Blastoma:

A

Cancer thought to arise from immature or embryonic tissue

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11
Q

80-90% of cancers are what type?

A

Carcinomas

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12
Q

Why are the majority of cancers carcinomas?

A

Epithelial cells are the site of extensive cell proliferation and frequent exposure to chemical and/or physical damage

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13
Q

Certain genes that are reported to play a critical role in cancer development:

A
  • DNA proofreading/ repair genes
  • Genes that maintain chromosomal integrity
  • Oncogenes
  • Tumour suppression genes
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14
Q

Tumour progression depends on various factors:

A
  • Mutation rate
  • Number of cells in the population
  • Rate of cell division
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15
Q

In a healthy cell, rate of damage is equal to ____

A

Rate of repair

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16
Q

During pathological situations, rate of DNA damage is ____ than the rate of repair:

A

Greater

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17
Q

How is the risk of developing cancer affected in an individual with inherited cellular DNA mutations?

A

Increased risk of developing cancer

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18
Q

Following mutations, oncogenes acquire ____

A

Gain-of-function

19
Q

Following mutations, tumour suppressor cells acquire ___

A

Loss-of-function

20
Q

What does gain-of-function refer to in mutated oncogenes?

A

Mutated oncogenes are expressed at high levels, resulting in cell growth & an increase in mitosis

21
Q

Examples of oncogenes:

A
  • Hormones
  • GFs
  • Receptors
  • Cell signaling molecules
  • TFs
22
Q

What is a tumour suppression gene’s main function?

A

To protect cells from cancer pathology

23
Q

End result following mutation of an oncogene or tumour suppressor gene:

A

Increase in cell growth

24
Q

The seven principles of cancer therapy:

A
  1. Cure requires death of all tumour cells
  2. Drugs kill a constant proportion of tumour
  3. Tumours detected later require prolonged treatment
  4. Drugs have narrow therapeutic index
  5. Drug combinations can increase effectiveness and decrease adverse cells
  6. Intermittent high-dose therapy is more effective
  7. Adjuvant therapy may decrease metastases
25
Q

Cancer therapy for terminal patients:

A

Palliative care, focuses on relieving and preventing suffering

26
Q

Localized therapies:

A

Surgery, radiation

27
Q

Systemic therapy:

A

Chemotherapy, hormone therapy (has effects on all regions of the body)

28
Q

The ultimate goal of pharmacologic cancer treatment:

A

Targeted therapy

29
Q

Factors influencing patient survival:

A
  • Time of initiation of treatment
  • Timing of the treatments
  • Drug combinations
30
Q

Cellular activity during G0 phase:

A

Cells cease division

31
Q

Cellular activity during G1 phase:

A

Cells grow

32
Q

Cellular activity during S phase:

A

DNA replicates

33
Q

Cellular activity during G2 phase:

A

Cells prepare to divide

34
Q

The addition of therapeutics during ___ phase would allow slow-growing tumours to be treated early:

A

Proliferative

35
Q

First-order kinetics:

A

Elimination of the drug is proportional to the plasma concentration of that same drug

36
Q

Chemotherapy kills cancer cells via:

A

First-order kinetics

37
Q

At the time of detection, how many cancerous cells are there?

A

Over one billion

38
Q

Failure of anticancer drugs can be due to:

A
  1. Lack of specificity (side effects and dosage limitations)
  2. Cancer has developed resistance to the treatment
39
Q

Ways cancerous cells may acquire resistance to treatment:

A
  1. Some neoplastic cells are inherently resistant
  2. Develop mutations through growth
  3. Multidrug resistance- A selection of cells expressing amplified p-glycoprotein that pumps drugs out of the cell
40
Q

Chemotherapy side effects:

A
  • Myelosuppression
  • Nausea, vomiting, diarrhea
  • Alopecia
  • Decreased sperm count, menopause, teratogenicity
  • Secondary carcinogenicity
41
Q

Ideal combination of cancer chemotherapy drugs:

A
  • Drugs that offer synergistic action
  • Drugs that have different mechanisms of action and resistance pathways
42
Q

Main things to consider when deciding on cancer treatment:

A
  • Long term gain vs. the risk
  • Chance of successful treatment vs. the quality of life
43
Q
A