Treatment in schizophrenia Flashcards

You may prefer our related Brainscape-certified flashcards:
1
Q

D2 receptor antagonist (dopamine) mesolimbic pathway

A

Haloperidol

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

which drug enhance cognition and concentration in schizophrenia along with antipsychotic properties?

A

Lurasidone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

extra pyramidal side effects?

A
  • acute dystonic reaction
  • Parkinsonism
  • tardive dyskinesia
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

dopaminergic side effects?

A
  • extra pyramidal side effects
  • neuroleptic malignant syndrome
  • hyperprolactinaemia
  • akathisia/ restless legs
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Neuroleptic malignant syndorme clinical picture?

A
  • rare
  • onset over hours (24-72)
    lasts for days untreated

Clinical presentation-
- increasing muscle tone
- pyrexia
- changing pulse/BP which then causes-
- rhabdo
- ARF
- coma
- death

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

NMS investigation?

A

creatinine kinase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

NMS treatment?

A

-stop antipsychotic
- rapid cooling
- renal support
- skeletal muscle relaxant- DANTROLINE
- dopamine agonists- BROMOCRIPTINE

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

what is prolactin- tuberoinfundibulnar situation?

A

-prolactin release is inhibited by dopamine
- blockage of dopamine leads to increased prolactin release

in female-
- galactorrhea
- decrease libido
- decrease arousal
- anorgasmia

in men-
- gynaecomastia
- erectile dysfunction
- oligospermia
- decrease libido

in both-
- decrease bone mineralisation
- decrease bone density leading to osteoporosis
- more falls and more fractures

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

treatment of akathisia?

A

akathisia is inability to sit for longer hours

1st line treatment- propranolol
2nd line- clonazepam (benzodiazepines)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

prolonged Qt interval cause?

A

caused by antipsychotics and Is one of the side effects of it

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

treatment resistant schizophrenia what should be given?

A

Clozapine

good for negative symptoms and antisuicidal

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

side effects of clozapine?

A
  • agranulocytosis > neutropenic sepsis
  • myocarditis
  • constipation–> perforation
  • weight gain
  • sedation
  • sialorrhoea
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

if a patient on antipsychotics present with falls

A

it is due to EPSE

How well did you know this?
1
Not at all
2
3
4
5
Perfectly