Treatment for Thyroid Conditions Flashcards
1
Q
What are symptoms of Hyperthyroidism?
A
- Anxiety
- Exophthalmos (bulging eyes)
- Goitre
- Tachycardia, Palpitations, Atrial fibrillation
- weight loss
- tremor
- diarrhoea
2
Q
What is Graves Disease?
A
= autoimmune condition where Abs bind to TSH receptor and cause excess thyroid hormone prod.
- form of Hyperthyroidism
3
Q
Diagnosis of Hyperthyroidism
A
- Low TSH
- High serum T4
4
Q
How to differentiate bw Primary and Secondary Hyperthyroidism
A
Primary:
- low TRH
- low TSH
- High T3 and T4
Secondary:
- low TRH
- higher TSH
- High T3 and T4
5
Q
Treatment for Graves’ Disease
A
Thiaonamides:
1. Carbimazole (first-line treatment)
2. Propylthiouracil
6
Q
What do Thionamides do?
A
- inhibit iodination of Tyrosine on thyroglobulin
- decrease T3/T4 synthesis
7
Q
AEs of Thionamides
A
- can cross the placenta -> causing congenital hypothyroidism
- Rashes
- Headaches, nausea, jaundice
8
Q
What does excess iodide do
A
- although iodide needed for T3/T4, excess iodide can inhibit release of T3/T4
9
Q
What are the clinical presentations of Hypothyroidism
A
- weight gain
- slowing of activities
10
Q
What happens to TRH, TSH and T3/T4 in HYpothyroidism?
A
- increased TRH
- increased TSH
- decreased T3 and T4
11
Q
Treatment for Hypothyroidism
A
T4 - used orally
T3 - used intravenously
Dietary iodine
