Treatment Abd Side Effects Of Antipsychotics

Question 1

Types of treatment

Answer 1

-pharmacological
-cognitive behavioural therapy(CBT)
-electroconvulsive therapy (ECT)

Question 2

What are antipsychotic/ neuroleptic drugs?

Answer 2

-Antipsychotic drugs (D2 antagonists)
-Typical or atypical (extrapyramidal effects/pharmacological profile)
-activity on Mesolimbic/mesocortical area- antipsychotic, sedation(rapid)
-activity in substantia nigra- motor effects
-antipsychotics- several weeks for effect

Question 3

What are the main DA pathways?

Answer 3

-Nigrostriatal pathway
-tubero-hypophyseal pathway
-mesocortical pathway
-mesolimbic pathway

ALL INVOLVED IN:
-movement
-cognition
-emotions
-motivation
-reward

Question 4

Antipsychotics-
Atypical and typical differences

Answer 4

Typical:
-‘first generation’
-first developed in 1950s
-mainly ANTAGONISE D2 receptors

Atypicals:
-‘second generation’
-first developed in 1980s
-mainly ANTAGONISE D2 receptors AND 5-HT2A receptors

Question 5

Receptor Blockade

Answer 5

• Beneficial for treating extrapyramidal side effects:
  .dry mouth
  .blurred vision
  .constipation
  .urinary retention

Antipsychotic: