Lecture 1

Question 1

Types of Central nervous system disorders?

Answer 1

→ addiction
→ OCD
→depression
→dementia
→Alzheimer’s

Question 2

CNS drugs in the top 30 include:

Answer 2

→diazepam - anxiolytic
→citalopram -antidepressant
→tramadol - pain

Question 3

Neurotransmission in the CNS:
-Fast point to point signalling

Answer 3

→ Fast point to point signalling
-neurotransmitters producing excitatory or inhibitory potentials
-ligand gated channels
- eg: glutamate, GABA, Ach

Question 4

Neurotransmission in the CNS:
- slow transmission

Answer 4

→ neurotransmitters and neuromodulators
→ g-protein coupled receptors.
→ eg: monoamines, peptides, ACh

Question 5

Ionotrophic receptor structure.

Answer 5

→different drugs have different binding sites at the receptor
→ ionotropic receptor examples:
- receptor -ion channel
GABA Cl-
Glycine Cl-
AMPA Na+. K+
NMDA Na+. K+. Ca2+
Nicotonic Na+. K+

Question 6

Families of g-proteins

Answer 6

• Gs - stimulates AC
  -Gi - inhibits AC
• Gq- activates PLC
  -Go- inhibits Ca2+ and k+ channels.

Question 7

Signalling cascade for GPCR

Answer 7

① transmitter (or hormone)
② activate receptor
③ G - protein
④ stimulates 2nd messenger eg adenylyl cycle
(ATP-cAMP)
⑤ protein kinase A phosphorylates potassium ion channels.